Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 5/20 | 0.39 |
| ▸ | MMP13 | P45452 | 5/20 | 0.39 |
| ▸ | MMP2 | P08253 | 3/20 | 0.39 |
| ▸ | MMP9 | P14780 | 3/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | MMP3 | P08254 | 2/20 | 0.36 |
| ▸ | MMP14 | P50281 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | SCN7A | Q01118 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7207163 | 0.88 | MMP1 (0.45) | MMP1MMP13MMP2MMP9MMP3 | |
| SCHEMBL7203051 | 0.85 | MMP1 (0.39) | MMP1MMP13MMP2MMP9MMP3 | |
| SCHEMBL7201292 | 0.85 | PARP10 (0.44) | MMP1MMP13MMP14ADAMTS4ALDH1A1 | |
| SCHEMBL7202625 | 0.85 | CCR6 (0.39) | MMP1MMP13MMP9 | |
| SCHEMBL7204248 | 0.83 | MMP1 (0.42) | MMP1MMP13MMP2MMP9BTK | |
| SCHEMBL7206530 | 0.83 | TSHR (0.45) | MMP1MMP13MMP2MMP9MMP3 | |
| SCHEMBL7199692 | 0.82 | PARP10 (0.41) | MMP1MMP13MMP2MMP9MMP3 | |
| SCHEMBL7203058 | 0.82 | MMP9 (0.47) | MMP1MMP13MMP2MMP9MMP3 | |
| SCHEMBL7204562 | 0.82 | MMP13 (0.51) | MMP1MMP13MMP2MMP9MMP3 | |
| SCHEMBL7204544 | 0.82 | MMP1 (0.41) | MMP1MMP13MMP2MMP9MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608104-B2 | Antiarthritic agents; anticancer agents | PFIZER INC | 2003-08-19 | — | — | US | disclosed |
| EP-1138680-A1 | Gem substituted sulfonyl hydroxamic acids as MMP inhibitors | Pfizer Products Inc. (US) | 2001-10-04 | — | — | EP | disclosed |