Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.62 |
| ▸ | MAPK13 | O15264 | 11/20 | 0.62 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.62 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.62 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.62 |
| ▸ | GCGR | P47871 | 6/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.62 |
| ▸ | FRK | P42685 | 2/20 | 0.62 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.62 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.62 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.62 |
| ▸ | GSK3B | P49841 | 2/20 | 0.62 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.62 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.62 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
| ▸ | RET | P07949 | 1/20 | 0.62 |
| ▸ | PRKACA | P17612 | 1/20 | 0.62 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.62 |
| ▸ | MATK | P42679 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7206018 | 0.84 | ALOX5 (0.64) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL13712660 | 0.84 | MAPK14 (0.83) | MAPK14MAPK13MAPK12MAPK11EGFR | |
| SCHEMBL4584929 | 0.82 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL7209162 | 0.81 | MAPK14 (0.55) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL1388020 | 0.77 | MAPK11 (1.00) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL22170123 | 0.77 | MAPK11 (1.00) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL2650007 | 0.75 | MAPK14 (0.81) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL4460400 | 0.75 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11EGFR | |
| SCHEMBL1131081 | 0.74 | MAPK13 (0.67) | MAPK14MAPK13MAPK12MAPK11ALOX5 | |
| SCHEMBL4585131 | 0.74 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994870-A4 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM (US) | 2002-10-23 | — | — | EP | claimed |
| EP-0994870-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | Smithkline Beecham (US) | 2000-04-26 | — | — | EP | claimed |
| WO-1998057966-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-12-23 | — | — | WO | claimed |
| US-6610695-B1 | Prophylaxis or treatment of CSBP/RK/p38 kinase mediated disease | SMITHKLINE BEECHAM CORPORATION | 2003-08-26 | — | — | US | disclosed |
| EP-0994870-A4 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM (US) | 2002-10-23 | — | — | EP | disclosed |
| EP-0994870-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | Smithkline Beecham (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998057966-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |