Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 11/20 | 0.60 |
| ▸ | STS | P08842 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR1E | P28566 | 1/20 | 0.50 |
| ▸ | HTR1F | P30939 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7200576 | 0.89 | HTR6 (0.58) | HTR6ALDH1A1KMT2ATGFBR1CYP1A2 | |
| SCHEMBL1612319 | 0.86 | HTR6 (0.54) | HTR6ALDH1A1KMT2ATGFBR1CYP1A2 | |
| SCHEMBL6975334 | 0.85 | HTR6 (0.82) | HTR6ALDH1A1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL855334 | 0.83 | HTR6 (0.51) | HTR6ALDH1A1KMT2ATGFBR1CYP1A2 | |
| SCHEMBL6980929 | 0.82 | HTR6 (0.85) | HTR6CYP1A2CYP3A4HTR1ACYP2D6 | |
| SCHEMBL7689845 | 0.81 | HTR6 (0.49) | HTR6STSALDH1A1KMT2AMAPT | |
| SCHEMBL12632946 | 0.80 | CYP2C9 (0.58) | HTR6STSALDH1A1KMT2AMAPT | |
| SCHEMBL7200046 | 0.80 | HTR6 (0.76) | HTR6CYP1A2CYP3A4HTR1ACYP2D6 | |
| SCHEMBL4212376 | 0.80 | STS (0.55) | HTR6STSMAPTTGFBR1HTR1A | |
| SCHEMBL1612888 | 0.78 | TGFBR1 (0.49) | HTR6TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6599904-B2 | 5-HT6 receptor antagonists are believed to be of potential use in the treatment of certain CNS disorders; cognitive memory enhancement | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-07-29 | — | — | US | disclosed |
| US-6423717-B1 | NERVOUS SYSTEM DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-07-23 | — | — | US | disclosed |