Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 11/20 | 0.49 |
| ▸ | F13A1 | P00488 | 3/20 | 0.47 |
| ▸ | TGM2 | P21980 | 3/20 | 0.47 |
| ▸ | TGM1 | P22735 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 3/20 | 0.47 |
| ▸ | HTR1D | P28221 | 3/20 | 0.47 |
| ▸ | HTR1B | P28222 | 3/20 | 0.47 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | HTR1E | P28566 | 1/20 | 0.45 |
| ▸ | HTR1F | P30939 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971247 | 0.83 | HTR6 (0.64) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL7206261 | 0.81 | HTR6 (0.60) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL20036032 | 0.80 | ALDH1A1 (0.66) | MAPTMEN1ALDH1A1ALOX15KMT2A | |
| SCHEMBL27830586 | 0.78 | HTR6 (0.42) | HTR6F13A1TGM2TGM1HTR1A | |
| SCHEMBL7200576 | 0.78 | HTR6 (0.58) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL3920345 | 0.77 | GRM5 (0.53) | MAPTMEN1ALDH1A1KMT2ASTS | |
| SCHEMBL1612319 | 0.77 | HTR6 (0.54) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL12152314 | 0.76 | PKLR (0.45) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL7200046 | 0.76 | HTR6 (0.76) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL12632946 | 0.75 | CYP2C9 (0.58) | HTR6HTR1AHTR1DHTR1BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423717-B1 | NERVOUS SYSTEM DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-07-23 | — | — | US | disclosed |