Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7205226 | 0.81 | CES1 (0.47) | MAPTRAB9ACES1CES2L3MBTL1 | |
| SCHEMBL4857310 | 0.78 | MAPK8 (0.56) | MAPK8L3MBTL1KMT2ATSHRMEN1 | |
| SCHEMBL4850980 | 0.76 | MAPK8 (0.50) | MAPTRAB9AMAPK8KMT2AALDH1A1 | |
| SCHEMBL24512733 | 0.74 | MAPT (0.47) | MAPTRAB9AL3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL4859054 | 0.73 | TDP1 (0.51) | MAPTRAB9AMAPK8ALDH1A1CYP1A2 | |
| SCHEMBL8456373 | 0.73 | MAPK8 (0.48) | MAPTMAPK8KMT2AALDH1A1CYP1A2 | |
| SCHEMBL10020220 | 0.73 | CES1 (0.52) | RAB9ACES1CES2KMT2AALDH1A1 | |
| SCHEMBL7469883 | 0.70 | MAPK8 (0.46) | MAPTRAB9AMAPK8L3MBTL1MAPK14 | |
| SCHEMBL5771051 | 0.70 | CES1 (0.47) | MAPTCES1CES2L3MBTL1MAPK14 | |
| SCHEMBL14747021 | 0.69 | MAPK8 (0.42) | MAPTRAB9AMAPK8MAPK14KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610695-B1 | Prophylaxis or treatment of CSBP/RK/p38 kinase mediated disease | SMITHKLINE BEECHAM CORPORATION | 2003-08-26 | — | — | US | disclosed |
| EP-0994870-A4 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM (US) | 2002-10-23 | — | — | EP | disclosed |
| EP-0994870-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | Smithkline Beecham (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998057966-A1 | NOVEL ARYLOXY SUBSTITUTED PYRIMIDINE IMIDAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |