Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.44 |
| ▸ | FPR2 | P25090 | 1/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 3/20 | 0.41 |
| ▸ | MET | P08581 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30740799 | 0.87 | RAB9A (0.49) | MAPTP2RX3SCN9AALOX5APFEN1 | |
| SCHEMBL4859054 | 0.85 | TDP1 (0.51) | MAPTP2RX3RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL3140118 | 0.82 | SCN9A (0.57) | MAPTSCN9AFPR2 | |
| SCHEMBL24512734 | 0.78 | P2RX3 (0.56) | P2RX3SCN9AFPR2PDGFRAKDR | |
| SCHEMBL22518516 | 0.78 | MAPK1 (0.44) | MAPTALOX5APFEN1RAB9ASMN1; SMN2 | |
| SCHEMBL27287238 | 0.75 | MAPT (0.45) | MAPTL3MBTL1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL753224 | 0.75 | MAPK1 (0.54) | MAPTL3MBTL1P2RX3SCN9AFPR2 | |
| SCHEMBL7206668 | 0.74 | MAPT (0.44) | MAPTL3MBTL1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL31128877 | 0.74 | MAPT (0.42) | MAPTL3MBTL1ALOX5APFEN1MET | |
| SCHEMBL24920948 | 0.73 | ACACB (0.42) | MAPTP2RX3ALOX5APFEN1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220185815-A1 | PYRROLOPYRAZOLE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2022-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220185815-A1 | PYRROLOPYRAZOLE DERIVATIVE | PTDSS1, PTDSS2, SMPD1 | MAPT 4781/4885L3MBTL1 3807/4885P2RX3 2893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.