Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA4 | P22748 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.47 |
| ▸ | NT5E | P21589 | 9/20 | 0.46 |
| ▸ | PDE2A | O00408 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | CD99 | P14209 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7206694 | 0.95 | ADORA3 (0.54) | ADORA3ALDH1A1LMNATP53MAPT | |
| SCHEMBL7208800 | 0.90 | ADORA3 (0.49) | ADORA3ALDH1A1LMNATP53MAPT | |
| Acetic Acid SCHEMBL7206675 | 0.88 | ADORA3 (0.59) | ADORA3CA1CA2CA4CA9 | |
| SCHEMBL7208805 | 0.85 | ADORA3 (0.51) | ADORA3ALDH1A1LMNATP53MAPT | |
| Acetic Acid SCHEMBL7208795 | 0.77 | ADORA3 (0.57) | ADORA3CA1CA2CA4CA9 | |
| SCHEMBL7205240 | 0.76 | ADORA3 (0.48) | ADORA3LMNATP53CA1CA2 | |
| SCHEMBL19837866 | 0.76 | ALDH1A1 (0.66) | ADORA3ALDH1A1LMNATP53MAPT | |
| SCHEMBL10026390 | 0.75 | ALDH1A1 (0.59) | ADORA3ALDH1A1LMNATP53MAPT | |
| SCHEMBL19837861 | 0.75 | ALDH1A1 (0.64) | ADORA3ALDH1A1LMNATP53MAPT | |
| SCHEMBL19837845 | 0.73 | ALDH1A1 (0.57) | ADORA3ALDH1A1LMNATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610665-B1 | Treatment of inflammatory diseases, asthma or chronic obstructive pulmonary disease | SMITHKLINE BEECHAM CORPORATION | 2003-08-26 | — | — | US | disclosed |
| EP-1056759-B1 | 2-(PURIN-9-YL) -TETRAHYDROFURAN-3, 4-DIOL DERIVATIVES | GLAXO GROUP LTD (GB) | 2002-09-04 | — | — | EP | disclosed |
| EP-1056759-A1 | 2-(PURIN-9-YL) -TETRAHYDROFURAN-3, 4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999041267-A1 | 2-(PURIN-9-YL) -TETRAHYDROFURAN-3, 4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |