Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 1.00 |
| ▸ | DRD4 | P21917 | 8/20 | 1.00 |
| ▸ | DRD3 | P35462 | 8/20 | 1.00 |
| ▸ | HTR1A | P08908 | 4/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.60 |
| ▸ | HTR1B | P28222 | 1/20 | 0.60 |
| ▸ | HTR6 | P50406 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7211796 | 0.85 | HTR1A (0.73) | DRD2DRD4DRD3HTR1ASLC6A4 | |
| SCHEMBL1582569 | 0.83 | DRD2 (0.70) | DRD2DRD4DRD3HTR1ASLC6A4 | |
| Hydrochloric Acid SCHEMBL1582607 | 0.82 | DRD2 (0.69) | DRD2DRD4DRD3HTR1ASLC6A4 | |
| SCHEMBL15265981 | 0.82 | DRD2 (0.68) | DRD2DRD4DRD3HTR1ASLC6A4 | |
| SCHEMBL15264971 | 0.81 | DRD2 (0.68) | DRD2DRD4DRD3HTR1ASLC6A4 | |
| SCHEMBL12629127 | 0.81 | DRD2 (0.68) | DRD2DRD4DRD3HTR1ASLC6A4 | |
| SCHEMBL12629128 | 0.80 | DRD2 (0.67) | DRD2DRD4DRD3HTR1ASLC6A4 | |
| SCHEMBL15265869 | 0.79 | DRD2 (0.63) | DRD2DRD4DRD3HTR1ASLC6A4 | |
| SCHEMBL16468242 | 0.79 | DRD2 (0.64) | DRD2DRD4DRD3HTR1ASLC6A4 | |
| SCHEMBL8612003 | 0.79 | DRD4 (1.00) | DRD2DRD4DRD3HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0923548-B1 | 4-AMINOETHOXY INDOLES AS DOPAMIN D2 AGONISTS AND AS 5HT 1A LIGANDS | WYETH CORP (US) | 2003-03-12 | — | — | EP | claimed |
| US-5958965-A | TREATMENT OF DISEASES ATTENDING DISTURBANCES IN THE SEROTINERGIC SYSTEMS, SUCH AS ANXIETY, STRESS, DEPRESSION, SEXUAL DYSFUNCTIONS AND SLEEP DISTURBANCES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-09-28 | — | — | US | claimed |
| EP-0923548-A1 | 4-AMINOETHOXY INDOLES AS DOPAMIN D2 AGONISTS AND AS 5HT 1A? LIGANDS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-06-23 | — | — | EP | claimed |
| WO-1998008817-A1 | 4-AMINOETHOXY INDOLES AS DOPAMIN D2 AGONISTS AND AS 5HT1A LIGANDS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-05 | — | — | WO | claimed |
| EP-0923548-B1 | 4-AMINOETHOXY INDOLES AS DOPAMIN D2 AGONISTS AND AS 5HT 1A LIGANDS | WYETH CORP (US) | 2003-03-12 | — | — | EP | disclosed |
| US-5958965-A | TREATMENT OF DISEASES ATTENDING DISTURBANCES IN THE SEROTINERGIC SYSTEMS, SUCH AS ANXIETY, STRESS, DEPRESSION, SEXUAL DYSFUNCTIONS AND SLEEP DISTURBANCES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-09-28 | — | — | US | disclosed |
| EP-0923548-A1 | 4-AMINOETHOXY INDOLES AS DOPAMIN D2 AGONISTS AND AS 5HT 1A? LIGANDS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-06-23 | — | — | EP | disclosed |
| WO-1998008817-A1 | 4-AMINOETHOXY INDOLES AS DOPAMIN D2 AGONISTS AND AS 5HT1A LIGANDS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-05 | — | — | WO | disclosed |