Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.42 |
| ▸ | RXRA | P19793 | 3/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.42 |
| ▸ | CPT1A | P50416 | 2/20 | 0.40 |
| ▸ | CPT2 | P23786 | 1/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2885375 | 0.81 | CRBN (0.52) | CRBNDDB1NPC1RAB9A | |
| SCHEMBL3663041 | 0.77 | UCHL1 (0.44) | HSD11B1CRBNDDB1NR1H2RXRA | |
| SCHEMBL6526185 | 0.77 | UCHL1 (0.44) | HSD11B1CRBNDDB1NR1H2RXRA | |
| SCHEMBL21611379 | 0.75 | RIPK1 (0.52) | RIPK1LMNANPSR1NPC1ALDH1A1 | |
| SCHEMBL22772314 | 0.75 | RIPK1 (0.52) | RIPK1LMNANPSR1NPC1ALDH1A1 | |
| SCHEMBL23064586 | 0.75 | RIPK1 (0.52) | RIPK1LMNANPSR1NPC1ALDH1A1 | |
| SCHEMBL22688967 | 0.75 | NPSR1 (0.54) | RIPK1LMNANPSR1NPC1ALDH1A1 | |
| SCHEMBL17151023 | 0.75 | NPSR1 (0.54) | RIPK1LMNANPSR1NPC1ALDH1A1 | |
| SCHEMBL27284775 | 0.74 | ALDH1A1 (0.42) | RIPK1LMNANPSR1NPC1ALDH1A1 | |
| SCHEMBL1778275 | 0.74 | NR1H2 (0.53) | NR1H2NR1H3RIPK1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912557-B1 | OXINDOLE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-07-09 | — | — | EP | disclosed |
| US-6265411-B1 | ANGIOGENESIS INHIBITOR | ZENECA LIMITED (GB) | 2001-07-24 | — | — | US | disclosed |
| EP-0912557-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1999-05-06 | — | — | EP | disclosed |
| WO-1997042187-A1 | OXINDOLE DERIVATIVES | ZENECA LIMITED (GB) | 1997-11-13 | — | — | WO | disclosed |