Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 2/20 | 0.42 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.42 |
| ▸ | MAT2A | P31153 | 3/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 5/20 | 0.34 |
| ▸ | FNTB | P49356 | 5/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | HCK | P08631 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7087571 | 0.89 | IDO1 (0.40) | IDO1PGGT1BFNTAFNTB | |
| SCHEMBL7091329 | 0.81 | IDO1 (0.39) | IDO1PGGT1BADORA2AADORA1FNTA | |
| SCHEMBL7091422 | 0.79 | GAA (0.41) | IDO1PGGT1BFNTAFNTB | |
| SCHEMBL5016765 | 0.74 | FNTA (0.46) | MAT2AIDO1PGGT1BFNTAFNTB | |
| SCHEMBL5655017 | 0.74 | FNTA (0.38) | IDO1PGGT1BFNTAFNTB | |
| SCHEMBL7205417 | 0.74 | IDO1 (0.43) | IDO1PGGT1BFNTAFNTB | |
| SCHEMBL7092843 | 0.73 | FNTA (0.53) | IDO1PGGT1BFNTAFNTB | |
| SCHEMBL5550225 | 0.71 | RORC (0.53) | FNTAFNTB | |
| SCHEMBL7210392 | 0.70 | IDO1 (0.52) | IDO1PGGT1BFNTAFNTB | |
| SCHEMBL7164435 | 0.66 | IDO1 (0.40) | IDO1PGGT1BKCNA5FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322650-A2 | FARNESYL TRANSFERASE INHIBITING 6-HETEROCYCLYLMETHYL QUINOLINE AND QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024686-A2 | FARNESYL TRANSFERASE INHIBITING 6-HETEROCYCLYLMETHYL QUINOLINE AND QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-03-28 | — | — | WO | disclosed |