Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 9/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6506686 | 0.84 | ELANE (0.43) | ELANEATML3MBTL1NPC1RAB9A | |
| SCHEMBL6720403 | 0.78 | CA2 (0.35) | — | |
| SCHEMBL6509256 | 0.75 | ELANE (0.47) | ELANEATML3MBTL1MAPTTDP1 | |
| SCHEMBL6508374 | 0.73 | ELANE (0.44) | ELANEATML3MBTL1MAPTTDP1 | |
| SCHEMBL7215625 | 0.71 | — | — | |
| SCHEMBL6183996 | 0.69 | RIPK1 (0.53) | ELANEATML3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6533915 | 0.69 | HRH3 (0.33) | ELANEALDH1A1SMN1; SMN2 | |
| SCHEMBL7202384 | 0.68 | ELANE (0.44) | ELANEATML3MBTL1MAPTTDP1 | |
| SCHEMBL2736910 | 0.67 | ELANE (0.49) | ELANEATML3MBTL1LMNAMAPT | |
| SCHEMBL6180739 | 0.67 | ELANE (0.43) | ELANEATML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002030882-A9 | SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES | ESPERION THERAPEUTICS INC (US) | 2003-02-20 | — | — | WO | disclosed |