SCHEMBL7207547

SCHEMBL7207547

CC(C)c1[c]c(C(C)C)c(C(=O)C(c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.43
TDP1 Q9NUW8 1/20 0.43
LMNA P02545 2/20 0.35
HDAC3 O15379 1/20 0.35
HDAC4 P56524 1/20 0.35
HDAC1 Q13547 1/20 0.35
HDAC7 Q8WUI4 1/20 0.35
HDAC2 Q92769 1/20 0.35
HDAC10 Q969S8 1/20 0.35
HDAC11 Q96DB2 1/20 0.35
HDAC8 Q9BY41 1/20 0.35
HDAC6 Q9UBN7 1/20 0.35
HDAC9 Q9UKV0 1/20 0.35
HDAC5 Q9UQL6 1/20 0.35
CES2 O00748 1/20 0.35
CES1 P23141 1/20 0.35
CTSD P07339 1/20 0.34
POLB P06746 2/20 0.33
PTGS2 P35354 1/20 0.33
MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7211283 0.88 PTGS2 (0.40) L3MBTL1TDP1LMNACES2CES1
SCHEMBL7207786 0.81 CHRM2 (0.41) LMNAPOLBSMN1; SMN2TSHRKDM4E
SCHEMBL7211946 0.78 CHRM3 (0.45) LMNAMAPTOPRM1TSHRCHRM2
SCHEMBL7207551 0.73 L3MBTL1 (0.56) L3MBTL1TDP1LMNAHDAC3HDAC4
SCHEMBL7211852 0.70 HRH3 (0.42) TDP1HDAC4SMN1; SMN2ALDH1A1HPGD
SCHEMBL7206358 0.70 HDAC3 (0.37) HDAC3HDAC4HDAC7HDAC8HDAC6
SCHEMBL15105762 0.66 L3MBTL1 (0.56) L3MBTL1TDP1HDAC3HDAC4HDAC1
SCHEMBL7212856 0.66 AKR1B1 (0.41) L3MBTL1LMNAPOLBMAPTKDM4E
SCHEMBL7211288 0.64 PTGS2 (0.41) L3MBTL1TDP1LMNACES2CES1
SCHEMBL2927912 0.62 L3MBTL1 (1.00) L3MBTL1TDP1LMNAHDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0841913-B1 USE OF SULFAMIC ACID DERIVATIVES, ACYL SULFONAMIDES OR SULFONYL CARBAMATES FOR THE MANUFACTURE OF A MEDICAMENT FOR LOWERING LIPOPROTEIN LEVELS WARNER LAMBERT CO (US) 2003-02-05 EP claimed
EP-0841913-A1 USE OF SULFAMIC ACID DERIVATIVES, ACYL SULFONAMIDES OR SULFONYL CARBAMATES FOR THE MANUFACTURE OF A MEDICAMENT FOR LOWERING LIPOPROTEIN LEVELS WARNER-LAMBERT COMPANY (US) 1998-05-20 EP claimed
WO-1997005868-A1 USE OF SULFAMIC ACID DERIVATIVES, ACYL SULFONAMIDES OR SULFONYL CARBAMATES FOR THE MANUFACTURE OF A MEDICAMENT FOR LOWERING LIPOPROTEIN LEVELS WARNER-LAMBERT COMPANY (US) 1997-02-20 WO claimed