Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 5/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL15653018 | 1.00 | HCAR2 (0.57) | HCAR2THRBTSHRGLO1ALDH1A1 | |
| Fumaric Acid SCHEMBL8953356 | 1.00 | HCAR2 (0.57) | HCAR2THRBTSHRGLO1ALDH1A1 | |
| Acrylic Acid SCHEMBL27651708 | 0.88 | THRB (0.52) | HCAR2THRBTSHRGLO1ALDH1A1 | |
| Acrylic Acid SCHEMBL265149 | 0.88 | THRB (0.52) | HCAR2THRBTSHRGLO1ALDH1A1 | |
| Acetic Acid SCHEMBL28298395 | 0.87 | THRB (0.59) | THRBTSHRGLO1ALDH1A1LMNA | |
| Bicarbonate SCHEMBL10996730 | 0.87 | THRB (0.59) | THRBTSHRGLO1ALDH1A1LMNA | |
| SCHEMBL15030 | 0.87 | — | — | |
| SCHEMBL19409375 | 0.87 | THRB (0.64) | THRBTSHRGLO1ALDH1A1LMNA | |
| Acrylic Acid SCHEMBL23825514 | 0.86 | THRB (0.50) | HCAR2THRBTSHRGLO1ALDH1A1 | |
| Acrolein SCHEMBL11765226 | 0.85 | HCAR2 (0.43) | HCAR2THRBTSHRGLO1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 83 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210214573-A1 | PHOTOPOLYMERIZABLE TYPE DENTAL SURFACE COATING COMPOSITION | SHOFU INC. (JP) | 2021-07-15 | — | — | US | disclosed |
| US-20200253835-A1 | Dental Curable Composition | TOKUYAMA DENTAL CORPORATION (JP) | 2020-08-13 | — | — | US | disclosed |
| EP-3682862-A1 | CURABLE DENTAL COMPOSITION | Tokuyama Dental Corporation (JP) | 2020-07-22 | — | — | EP | disclosed |
| EP-1704845-B1 | Polymerization initiator composition for dental or surgical adhesive compositions | SUN MEDICAL CO LTD (JP) | 2019-07-03 | — | — | EP | disclosed |
| EP-2902007-B1 | DENTAL FILLING REPAIRING MATERIAL | TOKUYAMA DENTAL CORP (JP) | 2019-01-09 | — | — | EP | disclosed |
| US-9192693-B2 | Method for treatment of emphysema | TERUMO KABUSHIKI KAISHA (JP) | 2015-11-24 | — | — | US | disclosed |
| US-20150272833-A1 | Dental Restorative Material | TOKUYAMA DENTAL CORPORATION (JP) | 2015-10-01 | — | — | US | disclosed |
| EP-2902007-A1 | DENTAL FILLING REPAIRING MATERIAL | Tokuyama Dental Corporation (JP) | 2015-08-05 | — | — | EP | disclosed |
| EP-2809688-A1 | LASER ENGRAVEABLE COMPOSITIONS FOR RELIEF IMAGE PRINTING ELEMENTS | NAPP SYSTEMS, INC. (US) | 2014-12-10 | — | — | EP | disclosed |
| WO-2013116011-A1 | LASER ENGRAVEABLE COMPOSITIONS FOR RELIEF IMAGE PRINTING ELEMENTS | NAPP SYSTEMS, INC. (US) | 2013-08-08 | — | — | WO | disclosed |
| US-5021321-A | Photothermography; antifogging agents; contrast; lamination of matrix of silver salts and reducing agent and dispersed particles of dye, polymer precursor and photoinitiator | CANON KABUSHIKI KAISHA (JP) | 1991-06-04 | — | — | US | disclosed |
| US-5001032-A | Photosensitive material containing a photosensitive and heat developable element and a polymerizable layer and image-forming method utilizing the same | CANON KABUSHIKI KAISHA (JP) | 1991-03-19 | — | — | US | disclosed |
| EP-0412851-A2 | Photosensitive member and multi-color image forming method | CANON KABUSHIKI KAISHA (JP) | 1991-02-13 | — | — | EP | disclosed |
| EP-0410803-A2 | Image forming device | CANON KABUSHIKI KAISHA (JP) | 1991-01-30 | — | — | EP | disclosed |
| EP-0363790-A2 | Image forming method and image forming medium | CANON KABUSHIKI KAISHA (JP) | 1990-04-18 | — | — | EP | disclosed |
| EP-0360014-A1 | Photosensitive material and image forming method using same | CANON KABUSHIKI KAISHA (JP) | 1990-03-28 | — | — | EP | disclosed |
| EP-0332455-A2 | Photosensitive material and image forming method | CANON KABUSHIKI KAISHA (JP) | 1989-09-13 | — | — | EP | disclosed |
| EP-0330504-A2 | Photosensitive material and image forming method | CANON KABUSHIKI KAISHA (JP) | 1989-08-30 | — | — | EP | disclosed |
| EP-0328364-A2 | Photosensitive material | CANON KABUSHIKI KAISHA (JP) | 1989-08-16 | — | — | EP | disclosed |
| EP-0326424-A2 | Photosensitive composition, photosensitive material, and image forming method | CANON KABUSHIKI KAISHA (JP) | 1989-08-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200253835-A1 | Dental Curable Composition | SP1, H1-0, ERH | HCAR2 993/4885THRB 1005/4885TSHR 2813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.