Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | PTPRC | P08575 | 1/20 | 0.41 |
| ▸ | S100A4 | P26447 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2738746 | 0.88 | CYP3A4 (0.47) | TDP1MAPTCYP3A4ALDH1A1MEN1 | |
| SCHEMBL30389282 | 0.82 | MAPT (0.58) | TDP1MAPTCYP3A4ALDH1A1MEN1 | |
| SCHEMBL12821539 | 0.82 | KDM4E (0.49) | TDP1MAPTCYP3A4ALDH1A1MEN1 | |
| SCHEMBL31377032 | 0.82 | KDM4E (0.49) | TDP1MAPTCYP3A4ALDH1A1MEN1 | |
| SCHEMBL21051804 | 0.80 | ALDH1A1 (0.49) | TDP1MAPTCYP3A4ALDH1A1MEN1 | |
| SCHEMBL6775625 | 0.79 | MAPT (0.50) | TDP1MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL11684415 | 0.76 | TDP1 (0.65) | TDP1MAPTCYP3A4ALDH1A1MEN1 | |
| SCHEMBL264644 | 0.76 | XDH (0.51) | TDP1MAPTMEN1KMT2AGAA | |
| SCHEMBL5311953 | 0.75 | MAPT (0.60) | TDP1MAPTCYP3A4ALDH1A1MEN1 | |
| SCHEMBL3277817 | 0.74 | IDO1 (0.35) | NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977741-B1 | SUBSTITUTED PHENYL DERIVATIVES, THEIR PREPARATION AND USE | NEUROSEARCH AS (DK) | 2003-09-03 | — | — | EP | disclosed |
| US-6297261-B1 | POTENT CHLORIDE CHANNEL BLOCKERS; TREATMENT OF SICKLE CELL ANEMIA, BRAIN EDEMA FOLLOWING ISCHAEMIA OR TUMORS, DIARRHEA, HYPERTENSION (DIURETIC), OSTEOPOROSIS, AND FOR THE REDUCTION OF THE INTRAOCULAR PRESSURE | NEUROSEARCH A/S (DK) | 2001-10-02 | — | — | US | disclosed |
| US-4286090-A | BLOWING AGENTS; PROPELLANTS; EXPLOSIVES; IGNITERS | THE DOW CHEMICAL COMPANY (US) | 1981-08-25 | — | — | US | disclosed |