Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL375291 | 0.70 | KDM4E (0.57) | KDM4ESMN1; SMN2ALDH1A1GLAGAA | |
| SCHEMBL14088768 | 0.70 | MEN1 (0.47) | KDM4ESMN1; SMN2ALDH1A1GLAGAA | |
| SCHEMBL29013081 | 0.65 | KDM4E (0.54) | KDM4ESMN1; SMN2ALDH1A1GLAGAA | |
| Hydrochloric Acid SCHEMBL11864786 | 0.63 | PTPN1 (0.46) | KDM4ESMN1; SMN2ALDH1A1GLAGAA | |
| SCHEMBL86743 | 0.62 | NOS2 (0.48) | KDM4ESMN1; SMN2ALDH1A1GLAGAA | |
| SCHEMBL2427657 | 0.62 | KDM4E (1.00) | KDM4ESMN1; SMN2ALDH1A1GLAGAA | |
| SCHEMBL14629325 | 0.62 | KDM4E (0.46) | KDM4ESMN1; SMN2ALDH1A1GLAGAA | |
| SCHEMBL28665936 | 0.61 | KDM4E (0.64) | KDM4ESMN1; SMN2ALDH1A1GLAGAA | |
| Hydrochloric Acid SCHEMBL30228536 | 0.61 | KDM4E (0.96) | KDM4ESMN1; SMN2ALDH1A1GLAGAA | |
| SCHEMBL14259819 | 0.60 | CASP3 (0.41) | KDM4ESMN1; SMN2ALDH1A1GLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112010937-B | YIGSR modified pentacyclic piperazinedione and preparation and application thereof | 首都医科大学（CN） | 2023-01-13 | — | — | CN | disclosed |
| US-20030083230-A1 | Reversal of multidrug resistance in human colon carcinoma cells | AMERICAN CYANAMID COMPANY | 2003-05-01 | — | — | US | disclosed |
| US-6372775-B1 | ANTICANCER AGENT | AMERICAN CYANAMID COMPANY | 2002-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030083230-A1 | Reversal of multidrug resistance in human colon carcinoma cells | ABCC1, FOLR1, FOLR2 | KDM4E 4269/4885SMN1; SMN2 4878/4885ALDH1A1 1343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.