Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 5/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.40 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6001827 | 0.76 | PTPN11 (0.50) | PTPN11MAPK1SMN1; SMN2PTPN1CA2 | |
| SCHEMBL7208755 | 0.75 | PTPN11 (0.61) | PTPN11MAPK1SMN1; SMN2PTPN1CA2 | |
| SCHEMBL10933116 | 0.73 | ALDH1A1 (0.43) | ALDH1A1HPGDPTPN11CA2PTGS1 | |
| SCHEMBL17774980 | 0.72 | PTPN11 (0.67) | ALDH1A1HPGDPTPN11MAPK1SMN1; SMN2 | |
| SCHEMBL463003 | 0.72 | PTPN11 (0.53) | PTPN11MAPK1SMN1; SMN2PTPN1CA2 | |
| SCHEMBL2238680 | 0.72 | PTPN11 (0.45) | PTPN11MAPK1SMN1; SMN2PTPN1CA2 | |
| SCHEMBL31349819 | 0.71 | PTPN11 (0.47) | PTPN11MAPK1SMN1; SMN2PTPN1CA2 | |
| SCHEMBL2237299 | 0.71 | NR1H4 (0.51) | PTPN11MAPK1SMN1; SMN2PTPN1CA2 | |
| SCHEMBL12153756 | 0.70 | CA2 (0.61) | HPGDPTPN11MAPK1SMN1; SMN2PTPN1 | |
| SCHEMBL27793381 | 0.69 | PTPN11 (0.46) | ALDH1A1HPGDPTPN11MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003508382-A | — | — | 2003-03-04 | — | — | JP | claimed |
| EP-1212296-A1 | PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS | Sugen, Inc. (US) | 2002-06-12 | — | — | EP | claimed |
| WO-2001016097-A1 | PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS | SUGEN, INC. (US) | 2001-03-08 | — | — | WO | claimed |