Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 5/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.38 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6001827 | 0.85 | PTPN11 (0.50) | PTPN11MAPK1SMN1; SMN2PTPN1EPHX2 | |
| SCHEMBL2237299 | 0.79 | NR1H4 (0.51) | PTPN11MAPK1SMN1; SMN2PTPN1EPHX2 | |
| SCHEMBL2237081 | 0.75 | EPHX2 (0.46) | PTPN11MAPK1SMN1; SMN2PTPN1EPHX2 | |
| SCHEMBL2237085 | 0.74 | MAPK1 (0.44) | PTPN11MAPK1SMN1; SMN2PTPN1EPHX2 | |
| SCHEMBL7208208 | 0.72 | ALDH1A1 (0.50) | PTPN11MAPK1SMN1; SMN2PTPN1EPHX2 | |
| SCHEMBL3778179 | 0.69 | ADRA2C (0.47) | SMN1; SMN2EPHX2CA2CA1SLC6A2 | |
| SCHEMBL17774980 | 0.69 | PTPN11 (0.67) | PTPN11MAPK1SMN1; SMN2PTPN1CA2 | |
| SCHEMBL31349819 | 0.68 | PTPN11 (0.47) | PTPN11MAPK1SMN1; SMN2PTPN1CA2 | |
| SCHEMBL12153756 | 0.67 | CA2 (0.61) | PTPN11MAPK1SMN1; SMN2PTPN1CA2 | |
| SCHEMBL1758623 | 0.67 | PYCR1 (0.44) | SMN1; SMN2SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110195967-A1 | 2-ARYL-ACETIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPE PHA.R.MA S.P.A. (IT) | 2011-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110195967-A1 | 2-ARYL-ACETIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CXCR2, MMP8, CXCR1 | PTPN11 727/4885MAPK1 644/4885SMN1; SMN2 883/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.