⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7803128 | 0.78 | — | — | |
| SCHEMBL27416463 | 0.74 | LMNA (0.41) | — | |
| SCHEMBL386798 | 0.74 | — | — | |
| SCHEMBL28192681 | 0.74 | — | — | |
| SCHEMBL1019320 | 0.74 | ALDH1A1 (0.38) | — | |
| SCHEMBL915208 | 0.74 | — | — | |
| SCHEMBL11426729 | 0.74 | — | — | |
| SCHEMBL1281054 | 0.74 | — | — | |
| SCHEMBL17209979 | 0.72 | THRB (0.40) | — | |
| SCHEMBL30171 | 0.72 | THRB (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0471576-B1 | 6-substituted-tetrahydrobenz[cd]indoles | LILLY CO ELI (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1000621-A2 | Use of 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz (CD) indoles for treating motion sickness and vomiting | ELI LILLY AND COMPANY (US) | 2000-05-17 | — | — | EP | disclosed |
| US-5783590-A | ADJUSTMENT OF SEROTONIN CONCENTRATION IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-07-21 | — | — | US | disclosed |
| EP-0683155-B1 | Tetrahydrobenz cd indoles with serotonin regulatory activity | LILLY CO ELI (US) | 1998-07-01 | — | — | EP | disclosed |
| US-5750554-A | COMPOUNDS FOR TREATMENT OF ANXIETY, DEPRESSION, ANTISECRETORY AGENTS, HYPOTENSIVE AGENTS AND TREATMENT OF EATING PROBLEMS | ELI LILLY AND COMPANY (US) | 1998-05-12 | — | — | US | disclosed |
| US-5736562-A | MODIFY FUNCTION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-04-07 | — | — | US | disclosed |
| US-5674884-A | FOR TREATMENT OF SEROTONIN-RELATED DISORDERS | ELI LILLY AND COMPANY (US) | 1997-10-07 | — | — | US | disclosed |
| US-5665744-A | SEROTONIN FUNCTION MODIFIERS | ELI LILLY AND COMPANY (US) | 1997-09-09 | — | — | US | disclosed |
| US-5665743-A | SEROTONIN FUNCTION MODIFIERS | ELI LILLY AND COMPANY (US) | 1997-09-09 | — | — | US | disclosed |
| US-5665758-A | SEROTONIN FUNCTION MODIFIERS | ELI LILLY AND COMPANY (US) | 1997-09-09 | — | — | US | disclosed |
| US-5244912-A | Serotonin antagonist | ELI LILLY AND COMPANY (US) | 1993-09-14 | — | — | US | disclosed |
| US-5244911-A | Serotonin antagonist | ELI LILLY AND COMPANY (US) | 1993-09-14 | — | — | US | disclosed |
| US-5229410-A | 6-substituted-hexahydrobenz[cd]indoles | ELI LILLY AND COMPANY (US) | 1993-07-20 | — | — | US | disclosed |
| US-5229409-A | Antidepressant, tranquilizer | ELI LILLY AND COMPANY (US) | 1993-07-20 | — | — | US | disclosed |
| EP-0506363-A1 | 6-Heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[cd]indoles | ELI LILLY AND COMPANY (US) | 1992-09-30 | — | — | EP | disclosed |
| EP-0506369-A1 | 6-Heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz[CD]indoles | ELI LILLY AND COMPANY (US) | 1992-09-30 | — | — | EP | disclosed |
| EP-0471569-A1 | 6-Substituted-hexahydrobenz (CD) indoles | ELI LILLY AND COMPANY (US) | 1992-02-19 | — | — | EP | disclosed |
| EP-0471515-A1 | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes, 3-aminochromanes and 3-aminothiochromanes | ELI LILLY AND COMPANY (US) | 1992-02-19 | — | — | EP | disclosed |
| EP-0471576-A1 | 6-substituted-tetrahydrobenz[cd]indoles | ELI LILLY AND COMPANY (US) | 1992-02-19 | — | — | EP | disclosed |
| EP-0444854-A2 | 6-Substituted hexahydrobenz[cd]indoles | ELI LILLY AND COMPANY (US) | 1991-09-04 | — | — | EP | disclosed |