Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 4/20 | 1.00 |
| ▸ | MMP8 | P22894 | 3/20 | 1.00 |
| ▸ | MMP1 | P03956 | 2/20 | 1.00 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.68 |
| ▸ | MMP2 | P08253 | 3/20 | 0.47 |
| ▸ | MMP9 | P14780 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKLR | P30613 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7208461 | 1.00 | MMP13 (1.00) | MMP13MMP8MMP1ADAM17MMP2 | |
| SCHEMBL7208471 | 1.00 | MMP13 (1.00) | MMP13MMP8MMP1ADAM17MMP2 | |
| SCHEMBL7208473 | 1.00 | MMP13 (1.00) | MMP13MMP8MMP1ADAM17MMP2 | |
| SCHEMBL8438391 | 0.86 | MMP13 (0.74) | MMP13MMP8MMP1ADAM17MMP2 | |
| SCHEMBL27529540 | 0.81 | MMP13 (0.68) | MMP13MMP8MMP1MMP2MMP9 | |
| SCHEMBL1188309 | 0.79 | MMP13 (0.73) | MMP13MMP8MMP1ADAM17MMP2 | |
| SCHEMBL7212111 | 0.74 | MMP13 (1.00) | MMP13MMP8MMP1ADAM17MMP2 | |
| SCHEMBL10800122 | 0.73 | MMP13 (0.58) | MMP13MMP8MMP1MMP2MMP9 | |
| SCHEMBL30748417 | 0.73 | MMP13 (0.60) | MMP13MMP8MMP1MMP2MMP9 | |
| SCHEMBL6932129 | 0.72 | MMP9 (0.59) | MMP13MMP8MMP1ADAM17MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0939628-B1 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO CO (US) | 2003-03-05 | — | — | EP | disclosed |
| US-6013649-A | BOND DISORDERS; AUTOIMMUNE DISEASES; ANTITUMOR AGENTS | MONSANTO COMPANY (US) | 2000-01-11 | — | — | US | disclosed |
| EP-0939628-A4 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO CO (US) | 1999-12-22 | — | — | EP | disclosed |
| EP-0939628-A1 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1999-09-08 | — | — | EP | disclosed |
| WO-1998003164-A1 | THIOL SULFONE METALLOPROTEASE INHIBITORS | MONSANTO COMPANY (US) | 1998-01-29 | — | — | WO | disclosed |