Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 8/20 | 0.59 |
| ▸ | MMP2 | P08253 | 6/20 | 0.59 |
| ▸ | MMP1 | P03956 | 13/20 | 0.57 |
| ▸ | MMP13 | P45452 | 9/20 | 0.57 |
| ▸ | MMP8 | P22894 | 2/20 | 0.57 |
| ▸ | MMP3 | P08254 | 8/20 | 0.52 |
| ▸ | MMP7 | P09237 | 3/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27529540 | 0.86 | MMP13 (0.68) | MMP9MMP2MMP1MMP13MMP8 | |
| SCHEMBL8438391 | 0.85 | MMP13 (0.74) | MMP9MMP2MMP1MMP13MMP8 | |
| SCHEMBL1188309 | 0.81 | MMP13 (0.73) | MMP9MMP2MMP1MMP13MMP8 | |
| SCHEMBL13043174 | 0.77 | MMP13 (0.63) | MMP9MMP2MMP1MMP13MMP8 | |
| SCHEMBL4771067 | 0.77 | MMP13 (0.52) | MMP9MMP2MMP1MMP13MMP8 | |
| SCHEMBL7308413 | 0.77 | MMP9 (0.95) | MMP9MMP2MMP1MMP13MMP8 | |
| SCHEMBL7308416 | 0.77 | MMP9 (0.95) | MMP9MMP2MMP1MMP13MMP8 | |
| SCHEMBL17966724 | 0.75 | MMP13 (0.56) | MMP9MMP2MMP1MMP13MMP8 | |
| SCHEMBL8525263 | 0.74 | MMP9 (0.70) | MMP9MMP2MMP1MMP13MMP8 | |
| SCHEMBL27432261 | 0.74 | MMP9 (0.70) | MMP9MMP2MMP1MMP13MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0970046-B1 | N-HYDROXY-2-(ALKYL, ARYL, OR HETEROARYL SULFANYL, SULFINYL OR SULFONYL)-3-SUBSTITUTED ALKYL, ARYL OR HETEROARYLAMIDES AS MATRIX METALLOPROTEINASE INHIBITORS | WYETH CORP (US) | 2003-12-10 | — | — | EP | claimed |