Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.57 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | GHSR | Q92847 | 1/20 | 0.50 |
| ▸ | RORC | P51449 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7208558 | 0.87 | FFAR4 (0.53) | HTR6HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL7206707 | 0.83 | HDAC1 (0.53) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL3559870 | 0.80 | HDAC1 (0.62) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| Propane SCHEMBL7208109 | 0.79 | HTR6 (0.67) | HTR6HDAC1HDAC8HDAC3HDAC4 | |
| Propane SCHEMBL7213022 | 0.79 | HTR6 (0.67) | HTR6FFAR4SMN1; SMN2UCHL1FFAR1 | |
| SCHEMBL26530291 | 0.79 | GAA (0.68) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL6756075 | 0.79 | FFAR4 (0.68) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL14601690 | 0.79 | FFAR4 (0.68) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL28913958 | 0.79 | KIF11 (0.69) | HDAC1HDAC8HDAC3HDAC4HDAC7 | |
| SCHEMBL7258961 | 0.77 | HTR6 (0.72) | HTR6GHSRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077935-B1 | PHENYLSULFONAMIDE-PHENYLETHYLAMINES USEFUL AS DOPAMINE RECEPTORS | UPJOHN CO (US) | 2003-10-29 | — | — | EP | claimed |
| EP-1077935-A1 | PHENYLSULFONAMIDE-PHENYLETHYLAMINES USEFUL AS DOPAMINE RECEPTORS | PHARMACIA & UPJOHN COMPANY (US) | 2001-02-28 | — | — | EP | claimed |
| US-6103766-A | SUBSTITUTED OR UNSUBSTITUTED PHENYLSULFONAMIDE-PHENYLAMINE DERIVATIVES USEFUL FOR TREATING THE DISORDERS RELATED TO CENTRAL NERVOUS SYSTEM | PHARMACIA & UPJOHN COMPANY (US) | 2000-08-15 | — | — | US | claimed |
| WO-1999058499-A1 | PHENYLSULFONAMIDE-PHENYLETHYLAMINES USEFUL AS DOPAMINE RECEPTORS | PHARMACIA & UPJOHN COMPANY (US) | 1999-11-18 | — | — | WO | claimed |
| EP-1077935-B1 | PHENYLSULFONAMIDE-PHENYLETHYLAMINES USEFUL AS DOPAMINE RECEPTORS | UPJOHN CO (US) | 2003-10-29 | — | — | EP | disclosed |
| EP-1077935-A1 | PHENYLSULFONAMIDE-PHENYLETHYLAMINES USEFUL AS DOPAMINE RECEPTORS | PHARMACIA & UPJOHN COMPANY (US) | 2001-02-28 | — | — | EP | disclosed |
| US-6103766-A | SUBSTITUTED OR UNSUBSTITUTED PHENYLSULFONAMIDE-PHENYLAMINE DERIVATIVES USEFUL FOR TREATING THE DISORDERS RELATED TO CENTRAL NERVOUS SYSTEM | PHARMACIA & UPJOHN COMPANY (US) | 2000-08-15 | — | — | US | disclosed |
| WO-1999058499-A1 | PHENYLSULFONAMIDE-PHENYLETHYLAMINES USEFUL AS DOPAMINE RECEPTORS | PHARMACIA & UPJOHN COMPANY (US) | 1999-11-18 | — | — | WO | disclosed |