Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 8/20 | 0.47 |
| ▸ | ADAMTS7 | Q9UKP4 | 5/20 | 0.47 |
| ▸ | MMP13 | P45452 | 8/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.44 |
| ▸ | MMP2 | P08253 | 3/20 | 0.44 |
| ▸ | MMP14 | P50281 | 3/20 | 0.44 |
| ▸ | MMP1 | P03956 | 11/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.41 |
| ▸ | ADAMTS1 | Q9UHI8 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7212982 | 0.90 | ADAMTS5 (0.47) | ADAMTS5ADAMTS7MMP13ADAMTS4MMP2 | |
| SCHEMBL7213016 | 0.85 | ADAMTS5 (0.51) | ADAMTS5ADAMTS7MMP13ADAMTS4MMP2 | |
| SCHEMBL7213084 | 0.84 | ADAMTS5 (0.40) | ADAMTS5ADAMTS7MMP13ADAMTS4MMP2 | |
| SCHEMBL7207012 | 0.83 | MMP13 (0.49) | ADAMTS5ADAMTS7MMP13ADAMTS4MMP2 | |
| SCHEMBL7212996 | 0.82 | MMP1 (0.42) | ADAMTS5ADAMTS7MMP13ADAMTS4MMP2 | |
| SCHEMBL7214304 | 0.82 | MMP1 (0.37) | ADAMTS5ADAMTS7MMP13ADAMTS4MMP2 | |
| SCHEMBL7209169 | 0.82 | MMP1 (0.43) | ADAMTS5ADAMTS7MMP13ADAMTS4MMP2 | |
| SCHEMBL7208597 | 0.81 | ADAMTS5 (0.61) | ADAMTS5ADAMTS7MMP13ADAMTS4MMP2 | |
| SCHEMBL7214227 | 0.79 | ADAMTS5 (0.50) | ADAMTS5ADAMTS7MMP13ADAMTS4MMP2 | |
| SCHEMBL7209164 | 0.78 | ADAMTS5 (0.50) | ADAMTS5ADAMTS7MMP13ADAMTS4MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181285-B1 | 3-(ARYLSULFONYLAMINO)-TETRAHYDROFURAN-3-CARBOXYLIC ACID HYDROXAMIDES | PFIZER PROD INC (US) | 2003-10-08 | — | — | EP | disclosed |
| EP-1181285-A2 | 3-(ARYLSULFONYLAMINO)-TETRAHYDROFURAN-3-CARBOXYLIC ACID HYDROXAMIDES | Pfizer Products Inc. (US) | 2002-02-27 | — | — | EP | disclosed |
| US-6342521-B1 | DRUGS FOR TREATMENT OF ARTHRITIS | PFIZER INC. | 2002-01-29 | — | — | US | disclosed |
| WO-2000073294-A2 | 3-(ARYLSULFONYLAMINO)-TETRAHYDROFURAN-3-CARBOXYLIC ACID HYDROXAMIDES | PFIZER PRODUCTS INC. (US) | 2000-12-07 | — | — | WO | disclosed |