Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | NCF1 | P14598 | 9/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7212295 | 0.80 | ADORA2A (0.69) | MAPTBACE1ADORA2AADORA1TACR3 | |
| SCHEMBL7225702 | 0.80 | MAPT (0.46) | MAPTADORA2AADORA1TACR3RECQL | |
| SCHEMBL14424722 | 0.79 | MAPT (0.56) | MAPTNCF1RECQLKDM4ESLC6A2 | |
| SCHEMBL14424717 | 0.79 | MAPT (0.56) | MAPTNCF1RECQLKDM4ESLC6A2 | |
| SCHEMBL16307497 | 0.77 | KDM4E (0.49) | MAPTTACR3KDM4E | |
| SCHEMBL17434164 | 0.75 | BACE1 (0.56) | BACE1ADORA2AADORA1NCF1KDM4E | |
| SCHEMBL15212407 | 0.74 | ACP1 (0.56) | MAPTTACR3KDM4E | |
| SCHEMBL21885156 | 0.72 | MAPT (0.50) | MAPTRECQLKDM4ESLC6A2SLC6A4 | |
| SCHEMBL23610024 | 0.72 | MAPT (0.56) | MAPTRECQLKDM4ESLC6A2SLC6A4 | |
| SCHEMBL11390012 | 0.72 | MAPT (0.56) | MAPTRECQLKDM4ESLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608085-B1 | Administering for neuroprotection | VERNALIS RESEARCH LIMITED (GB) | 2003-08-19 | — | — | US | disclosed |
| EP-1107761-A2 | 4-QUINOLINEMETHANOL DERIVATIVES AS PURINE RECEPTOR ANTAGONISTS (II) | VERNALIS RESEARCH LIMITED (GB) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000013682-A2 | 4-QUINOLINEMETHANOL DERIVATIVES AS PURINE RECEPTOR ANTAGONISTS.(II) | VERNALIS RESEARCH LIMITED (GB) | 2000-03-16 | — | — | WO | disclosed |