Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4961573 | 1.00 | PDE7A (0.42) | PDE7AMAPTLMNASMN1; SMN2HPGD | |
| SCHEMBL7039626 | 0.93 | MEN1 (0.41) | PDE7AMAPTLMNASMN1; SMN2HPGD | |
| SCHEMBL6273901 | 0.89 | ALDH1A1 (0.41) | PDE7AMAPTLMNASMN1; SMN2HPGD | |
| SCHEMBL6274128 | 0.88 | MAPT (0.43) | PDE7AMAPTLMNASMN1; SMN2HPGD | |
| SCHEMBL14451769 | 0.85 | ALDH1A1 (0.47) | PDE7ALMNAALDH1A1POLBMEN1 | |
| SCHEMBL4963123 | 0.84 | HSPB1 (0.41) | PDE7AMAPTLMNASMN1; SMN2HPGD | |
| SCHEMBL6660363 | 0.84 | ALDH1A1 (0.57) | LMNASMN1; SMN2HPGDALDH1A1RAB9A | |
| SCHEMBL7042931 | 0.83 | MEN1 (0.43) | PDE7AMAPTLMNASMN1; SMN2HPGD | |
| SCHEMBL4964933 | 0.82 | CYP2C9 (0.43) | PDE7AMAPTLMNASMN1; SMN2HPGD | |
| SCHEMBL4961548 | 0.82 | L3MBTL1 (0.52) | SMN1; SMN2ALDH1A1NPSR1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268404-A1 | MALONAMIC ACIDS AND DERIVATIVES THEREOF AS THYROID RECEPTOR LIGANDS | Pfizer Products Inc. (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072692-A1 | MALONAMIC ACIDS AND DERIVATIVES THEREOF AS THYROID RECEPTOR LIGANDS | PFIZER PRODUCTS INC. (US) | 2001-10-04 | — | — | WO | disclosed |