Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 10/20 | 0.49 |
| ▸ | NAAA | Q02083 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 9/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4962625 | 0.96 | NAAA (0.50) | THRBNAAATHRAEPHX1EPHX2 | |
| SCHEMBL4965301 | 0.96 | THRB (0.53) | THRBNAAATHRAEPHX1EPHX2 | |
| SCHEMBL4962612 | 0.96 | THRB (0.53) | THRBNAAATHRAEPHX1EPHX2 | |
| SCHEMBL4964553 | 0.92 | THRB (0.55) | THRBNAAATHRAEPHX1EPHX2 | |
| SCHEMBL4961549 | 0.80 | NAAA (0.57) | THRBNAAATHRAEGFRSYK | |
| SCHEMBL4963095 | 0.80 | THRB (0.54) | THRBTHRAEPHX1EPHX2 | |
| SCHEMBL4962115 | 0.79 | THRB (0.55) | THRBTHRAEPHX1EPHX2 | |
| SCHEMBL6661525 | 0.78 | THRB (0.53) | THRBNAAATHRAEPHX2EGFR | |
| SCHEMBL4963239 | 0.78 | THRA (0.55) | THRBTHRAEPHX1EPHX2 | |
| SCHEMBL4962544 | 0.77 | NAAA (0.53) | THRBNAAATHRAEGFRSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268404-A1 | MALONAMIC ACIDS AND DERIVATIVES THEREOF AS THYROID RECEPTOR LIGANDS | Pfizer Products Inc. (US) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001072692-A1 | MALONAMIC ACIDS AND DERIVATIVES THEREOF AS THYROID RECEPTOR LIGANDS | PFIZER PRODUCTS INC. (US) | 2001-10-04 | — | — | WO | disclosed |