Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.76 |
| ▸ | NPC1 | O15118 | 8/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.76 |
| ▸ | CASP1 | P29466 | 1/20 | 0.76 |
| ▸ | HPGD | P15428 | 6/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.61 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.61 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | RELA | Q04206 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22441244 | 0.95 | RAB9A (0.69) | RAB9ANPC1SMN1; SMN2CASP1HPGD | |
| SCHEMBL28735058 | 0.94 | NPC1 (0.68) | RAB9ANPC1SMN1; SMN2CASP1HPGD | |
| SCHEMBL7564852 | 0.90 | RAB9A (0.79) | RAB9ANPC1SMN1; SMN2CASP1HPGD | |
| SCHEMBL29893174 | 0.88 | RAB9A (0.76) | RAB9ANPC1SMN1; SMN2CASP1HPGD | |
| SCHEMBL10943133 | 0.88 | RAB9A (0.86) | RAB9ANPC1SMN1; SMN2CASP1HPGD | |
| SCHEMBL7564856 | 0.87 | RAB9A (0.70) | RAB9ANPC1SMN1; SMN2CASP1HPGD | |
| SCHEMBL8132597 | 0.86 | RAB9A (1.00) | RAB9ANPC1SMN1; SMN2CASP1HPGD | |
| SCHEMBL30918894 | 0.85 | SMN1; SMN2 (0.68) | RAB9ANPC1SMN1; SMN2CASP1HPGD | |
| SCHEMBL13387589 | 0.85 | RAB9A (0.72) | RAB9ANPC1SMN1; SMN2CASP1HPGD | |
| SCHEMBL3765824 | 0.85 | RAB9A (0.69) | RAB9ANPC1SMN1; SMN2CASP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0921122-B1 | EPOXYSUCCINAMIDE DERIVATIVES OR SALTS THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2003-05-21 | — | — | EP | disclosed |
| US-6110967-A | USEFUL AS AGENTS FOR PREVENTING AND TREATING METABOLIC OSTEOPATHY SUCH AS OSTEOPOROSIS, HYPERCALCEMIA AND BONE METASTASIS OF CANCER BECAUSE THEY SPECIFICALLY INHIBITS CATHEPSIN L AND ITS FAMILY ENZYMES TO INHIBIT BONE RESORPTION | TAIHO PHARMACEUTICALS CO., LTD. (JP) | 2000-08-29 | — | — | US | disclosed |
| EP-0921122-A1 | NOVEL EPOXYSUCCINAMIDE DERIVATIVES OR SALTS THEREOF | TAIHO PHARMACEUTICAL COMPANY, LIMITED (JP) | 1999-06-09 | — | — | EP | disclosed |