Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 3/20 | 0.55 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 11/20 | 0.53 |
| ▸ | MMP9 | P14780 | 11/20 | 0.53 |
| ▸ | MMP8 | P22894 | 11/20 | 0.53 |
| ▸ | MMP14 | P50281 | 10/20 | 0.53 |
| ▸ | TACR1 | P25103 | 3/20 | 0.52 |
| ▸ | NMBR | P28336 | 1/20 | 0.52 |
| ▸ | MME | P08473 | 2/20 | 0.51 |
| ▸ | MMP11 | P24347 | 2/20 | 0.51 |
| ▸ | MMP7 | P09237 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4264837 | 0.85 | KMT2A (0.52) | ECE1TACR1 | |
| SCHEMBL5379545 | 0.84 | ALOX15 (0.59) | ECE1LNPEPMMP2MMP9NMBR | |
| SCHEMBL5379543 | 0.84 | ALOX15 (0.59) | ECE1LNPEPMMP2MMP9NMBR | |
| SCHEMBL7207869 | 0.83 | NPC1 (0.46) | ECE1TACR1MME | |
| SCHEMBL7209082 | 0.83 | NPC1 (0.46) | ECE1TACR1MME | |
| SCHEMBL27455388 | 0.77 | ACE (0.59) | ECE1MMP2MMP9MMP8NMBR | |
| SCHEMBL8862510 | 0.77 | ACE (0.59) | ECE1MMP2MMP9MMP8NMBR | |
| SCHEMBL8862514 | 0.77 | ACE (0.59) | ECE1MMP2MMP9MMP8NMBR | |
| SCHEMBL10420266 | 0.76 | TACR1 (0.67) | LNPEPTACR1NMBR | |
| SCHEMBL1711383 | 0.76 | NMBR (0.73) | ECE1MMP2MMP9MMP8MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150988-B1 | PHOSPHORAMIDATE, AND MONO-, DI-, AND TRI-PHOSPHATE ESTERS OF (1R, CIS)-4-(6-AMINO-9H-PURIN-9-YL)-2-CYCLOPENTENE-1-METHANOL AS ANTIVIRAL AGENTS | GLAXO GROUP LTD (GB) | 2003-05-28 | — | — | EP | claimed |