Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 5/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 3/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | HTR7 | P34969 | 3/20 | 0.38 |
| ▸ | HTR2B | P41595 | 3/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.38 |
| ▸ | DRD1 | P21728 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | HRH2 | P25021 | 2/20 | 0.38 |
| ▸ | HTR1D | P28221 | 2/20 | 0.38 |
| ▸ | HTR1B | P28222 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.38 |
| ▸ | HTR5A | P47898 | 2/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7620925 | 0.89 | HSD11B1 (0.44) | HSD11B1HTR2AGRM2LMNAKMT2A | |
| SCHEMBL4232496 | 0.82 | HSD11B1 (0.64) | HSD11B1HTR2AGRM2LMNAKMT2A | |
| SCHEMBL7209324 | 0.79 | HSD11B1 (0.48) | HSD11B1HTR2AGRM2LMNAKMT2A | |
| SCHEMBL4076354 | 0.79 | SIGMAR1 (0.49) | HTR1AHTR2CDRD2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL4071872 | 0.77 | SIGMAR1 (0.43) | KMT2ADRD2GAAALDH1A1MEN1 | |
| SCHEMBL4236994 | 0.74 | HTR2A (0.55) | HSD11B1HTR2AGRM2LMNAKMT2A | |
| Hydrochloric Acid SCHEMBL4236997 | 0.73 | HTR2A (0.54) | HSD11B1HTR2AGRM2LMNAKMT2A | |
| SCHEMBL14637537 | 0.72 | KMT2A (0.62) | HSD11B1LMNAKMT2AMGLLGAA | |
| SCHEMBL7097807 | 0.71 | HSD11B1 (0.57) | HSD11B1HTR2AGRM2LMNAKMT2A | |
| Trifluoroacetic Acid SCHEMBL22118447 | 0.70 | HTR2A (0.51) | HSD11B1HTR2AGRM2LMNAHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289527-A2 | USE OF (+)-ALPHA -(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL OR ITS PRODRUG IN THE TREATMENT OF SYMPTOMS OF DEMENTIA AND DOPAMINE INDUCED PSYCHOSIS | Aventis Pharmaceuticals Inc. (US) | 2003-03-12 | — | — | EP | disclosed |
| WO-2001089498-A2 | USE OF (+)-α -(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL OR ITS PRODRUG IN THE TREATMENT OF SYMPTOMS OF DEMENTIA AND DOPAMINE INDUCED PSYCHOSIS | AVENTIS PHARMA INC (US) | 2001-11-29 | — | — | WO | disclosed |