Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.74 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28249029 | 0.82 | CHRNA7 (0.57) | PTGS2MAPTKDM4EALDH1A1L3MBTL1 | |
| SCHEMBL2467810 | 0.77 | PTGS2 (0.63) | PTGS2CHRNA7PTGS1 | |
| SCHEMBL6343529 | 0.76 | RXRA (0.66) | PTGS2CHRNA7PTGS1 | |
| SCHEMBL7216760 | 0.75 | PTGS2 (0.59) | PTGS2KDM4EALDH1A1HSD17B10ALOX15 | |
| SCHEMBL7210689 | 0.75 | PTGS2 (0.77) | PTGS2CHRNA7PTGS1 | |
| SCHEMBL3021555 | 0.75 | PTGS2 (0.77) | PTGS2CHRNA7PTGS1 | |
| SCHEMBL247093 | 0.74 | MEN1 (0.65) | PTGS2MAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL9763027 | 0.74 | MEN1 (0.81) | MAPTKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL244044 | 0.73 | ADH5 (0.66) | PTGS2MAPTKDM4EALDH1A1MEN1 | |
| SCHEMBL20250909 | 0.72 | KDM4E (1.00) | PTGS2MAPTKDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1369415-A1 | Substituted pyrrolyl compounds for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2003-12-10 | — | — | EP | disclosed |
| EP-0946507-B1 | SUBSTITUTED PYRROLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2003-09-24 | — | — | EP | disclosed |
| EP-0946507-A1 | SUBSTITUTED PYRROLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998025896-A1 | SUBSTITUTED PYRROLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-06-18 | — | — | WO | disclosed |