Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 12/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7209967 | 0.93 | KDR (0.52) | SRCEGFRKDM1APDPK1EPHA2 | |
| SCHEMBL1734721 | 0.88 | KDM1A (0.57) | SRCABL1EGFRERBB2LYN | |
| SCHEMBL29478513 | 0.88 | KDM1A (0.57) | SRCABL1EGFRERBB2LYN | |
| SCHEMBL829762 | 0.88 | KDM1A (0.57) | SRCABL1EGFRERBB2LYN | |
| SCHEMBL29478512 | 0.88 | KDM1A (0.57) | SRCABL1EGFRERBB2LYN | |
| Hydrochloric Acid SCHEMBL4378504 | 0.87 | KDM1A (0.56) | SRCABL1EGFRERBB2LYN | |
| Hydrochloric Acid SCHEMBL27988356 | 0.87 | KDM1A (0.56) | SRCABL1EGFRERBB2LYN | |
| SCHEMBL5498950 | 0.83 | EHMT2 (0.54) | EGFREPHA2KDREPHB4 | |
| SCHEMBL4380551 | 0.82 | EHMT2 (0.53) | EGFREPHA2KDREPHB4 | |
| SCHEMBL7215157 | 0.82 | EGFR (0.48) | SRCEGFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080171874-A1 | METHOD FOR THE REGIOSELECTIVE PREPARATION OF SUBSTITUTED BENZO[G]QUINOLINE-3-CARBONITRILES AND BENZO[G]QUINAZOLINES | WYETH (US) | 2008-07-17 | — | — | US | disclosed |
| US-7365197-B2 | Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines | WYETH (US) | 2008-04-29 | — | — | US | disclosed |
| US-20060041127-A1 | Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines | WYETH | 2006-02-23 | — | — | US | disclosed |
| EP-1345889-A1 | METHOD FOR THE REGIOSELECTIVE PREPARATION OF SUBSTITUTED BENZO G]QUINOLINE-3-CARBONITRILES AND BENZO G]QUINAZOLINES | Wyeth (US) | 2003-09-24 | — | — | EP | disclosed |
| US-20020091273-A1 | Method for the regioselective preparation of substituted benzo[g]quinoline3-carbonitriles and benzo[g]quinazolines | AMERICAN HOME PRODUCTS CORPORATION | 2002-07-11 | — | — | US | disclosed |
| WO-2002053528-A1 | METHOD FOR THE REGIOSELECTIVE PREPARATION OF SUBSTITUTED BENZO[G]QUINOLINE-3-CARBONITRILES AND BENZO[G]QUINAZOLINES | WYETH (US) | 2002-07-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080171874-A1 | METHOD FOR THE REGIOSELECTIVE PREPARATION OF SUBSTITUTED BENZO[G]QUINOLINE-3-CARBONITRILES AND BENZO[G]QUINAZOLINES | PDXK, PKD1, GLS | SRC 1554/4885ABL1 210/4885EGFR 1517/4885 |
| US-20060041127-A1 | Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines | PDXK, PKD1, GLS | SRC 1554/4885ABL1 210/4885EGFR 1517/4885 |
| US-20020091273-A1 | Method for the regioselective preparation of substituted benzo[g]quinoline3-carbonitriles and benzo[g]quinazolines | PDXK, PKD1, PFKP | SRC 1645/4885ABL1 224/4885EGFR 1539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.