Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 13/20 | 0.69 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7216700 | 0.89 | PTGS2 (0.62) | PTGS2PTGS1KDM4EALDH1A1MAPT | |
| SCHEMBL7215252 | 0.87 | PTGS2 (0.53) | PTGS2PTGS1KDM4EALDH1A1MAPT | |
| SCHEMBL7216779 | 0.86 | PTGS2 (0.69) | PTGS2PTGS1ALDH1A1 | |
| SCHEMBL7215571 | 0.84 | PTGS2 (0.62) | PTGS2PTGS1CHRNA7PTGER1 | |
| SCHEMBL5311980 | 0.81 | PTGS2 (0.64) | PTGS2PTGS1CHRNA7KDM4EALDH1A1 | |
| SCHEMBL3026121 | 0.81 | CHRNA7 (0.60) | PTGS2PTGS1CHRNA7PTGER1 | |
| SCHEMBL5314020 | 0.81 | CHRNA7 (0.60) | PTGS2PTGS1CHRNA7PTGER1 | |
| SCHEMBL7216358 | 0.80 | PTGS2 (0.62) | PTGS2PTGS1 | |
| SCHEMBL8505153 | 0.79 | PTGS2 (0.48) | PTGS2PTGS1ALDH1A1MAPTHPGD | |
| SCHEMBL2466714 | 0.79 | PTGS2 (0.66) | PTGS2PTGS1CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1369415-A1 | Substituted pyrrolyl compounds for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2003-12-10 | — | — | EP | disclosed |