Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.72 |
| ▸ | MAPT | P10636 | 3/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.72 |
| ▸ | PKM | P14618 | 1/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NOS1 | P29475 | 3/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29559746 | 0.85 | MAPT (1.00) | MEN1KMT2AMAPTKDM4EPKM | |
| SCHEMBL177260 | 0.85 | MAPT (1.00) | MEN1KMT2AMAPTKDM4EPKM | |
| SCHEMBL14137873 | 0.83 | NOS1 (0.53) | MEN1KMT2AMAPTKDM4EPKM | |
| Bromide SCHEMBL2931157 | 0.83 | MAPT (0.96) | MEN1KMT2AMAPTKDM4EPKM | |
| Hydrochloric Acid SCHEMBL3871258 | 0.83 | MAPT (0.96) | MEN1KMT2AMAPTKDM4EPKM | |
| Bromide SCHEMBL2933643 | 0.83 | MAPT (0.96) | MEN1KMT2AMAPTKDM4EPKM | |
| Hydrochloric Acid SCHEMBL2925515 | 0.83 | MAPT (0.96) | MEN1KMT2AMAPTKDM4EPKM | |
| Hydrochloric Acid SCHEMBL29176224 | 0.82 | NOS1 (0.52) | MEN1KMT2AMAPTKDM4EPKM | |
| SCHEMBL28140797 | 0.74 | MAPT (0.77) | MEN1KMT2AMAPTKDM4EPKM | |
| SCHEMBL3105606 | 0.73 | ROCK2 (0.53) | MEN1KMT2AMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1339702-A1 | 5-AMIDE SUBSTITUTED DIARYLAMINES AS MEK INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2003-09-03 | — | — | EP | disclosed |
| WO-2001068619-A1 | 5-AMIDE SUBSTITUTED DIARYLAMINES AS MEX INHIBITORS | WARNER-LAMBERT COMPANY (US) | 2001-09-20 | — | — | WO | disclosed |