Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 1/20 | 0.53 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | FAAH | O00519 | 2/20 | 0.50 |
| ▸ | CNR2 | P34972 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.45 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.45 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.44 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.44 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | CTSG | P08311 | 1/20 | 0.42 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7208665 | 0.93 | SLC6A5 (0.60) | DNM1SLC6A5MEN1KMT2AFAAH | |
| SCHEMBL7215936 | 0.93 | SLC6A5 (0.60) | DNM1SLC6A5MEN1KMT2AFAAH | |
| SCHEMBL7209771 | 0.93 | SLC6A5 (0.60) | DNM1SLC6A5MEN1KMT2AFAAH | |
| SCHEMBL7208460 | 0.93 | SLC6A5 (0.60) | DNM1SLC6A5MEN1KMT2AFAAH | |
| SCHEMBL29234719 | 0.86 | DNM1 (0.62) | DNM1SLC6A5MEN1KMT2AFAAH | |
| SCHEMBL116434 | 0.86 | DNM1 (0.62) | DNM1SLC6A5MEN1KMT2AFAAH | |
| SCHEMBL115472 | 0.86 | DNM1 (0.62) | DNM1SLC6A5MEN1KMT2AFAAH | |
| SCHEMBL16011427 | 0.79 | FAAH (0.66) | DNM1MEN1KMT2AFAAHMAPK1 | |
| SCHEMBL16011423 | 0.79 | FAAH (0.66) | DNM1MEN1KMT2AFAAHMAPK1 | |
| SCHEMBL15007772 | 0.79 | FAAH (0.66) | DNM1MEN1KMT2AFAAHMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920434-A3 | BIS-PLATINUM COMPLEXES WITH POLYMETHYLENE DERIVATIVES AS LIGANDS HAVING ANTITUMOR ACTIVITY | F.HOFFMANN-LA ROCHE AG (CH) | 2003-06-04 | — | — | EP | disclosed |
| EP-0912584-B1 | NEW BIS-PLATINUM COMPLEXES WITH POLYAMINE LIGANDS AS ANTITUMOR AGENTS | HOFFMANN LA ROCHE (CH) | 2002-12-18 | — | — | EP | disclosed |
| EP-0920434-B1 | BIS-PLATINUM COMPLEXES WITH POLYMETHYLENE DERIVATIVES AS LIGANDS HAVING ANTITUMOR ACTIVITY | HOFFMANN LA ROCHE (CH) | 2002-10-16 | — | — | EP | disclosed |
| US-6060616-A | ANTITUMORS AGENTS; LEUKEMIA, OVARIAN CARCINOMA | HOFFMANN-LA ROCHE INC. (US) | 2000-05-09 | — | — | US | disclosed |
| US-6022892-A | Bis-platinum complexes with polyamine ligands as antitumor agents | HOFFMAN-LA ROCHE INC. (US) | 2000-02-08 | — | — | US | disclosed |
| EP-0920434-A2 | BIS-PLATINUM COMPLEXES WITH POLYMETHYLENE DERIVATIVES AS LIGANDS HAVING ANTITUMOR ACTIVITY | F.HOFFMANN-LA ROCHE AG (CH) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998003519-A9 | NEW BIS-PLATINUM COMPLEXES WITH POLYAMINE LIGANDS AS ANTITUMOR AGENTS | — | 1998-07-16 | — | — | WO | disclosed |
| WO-1998003518-A2 | NEW BIS-PLATINUM COMPLEXES WITH POLYMETHYLENE DERIVATIVES AS LIGANDS HAVING ANTITUMOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-01-29 | — | — | WO | disclosed |