SCHEMBL7211237

COc1ccc(C(=O)N(C)CCOP(O[C@@]2(O)C[C@H](n3cc(C)c(=O)[nH]c3=O)O[C@@H]2COC(c2ccccc2)(c2ccc(OC)cc2)c2ccc(OC)cc2)N(C(C)C)C(C)C)cc1

nearest known ligand 0.35

Predicted protein targets (top 4)

	gene	UniProt	supporting neighbours	confidence
▸	TK2	O00142	11/20	0.35

▸	RNASE1	P07998	1/20	0.33

▸	TK1	P04183	4/20	0.33

▸	TERT	O14746	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL7207527	0.99	RNASE1 (0.34)	TK2RNASE1TK1TERT
SCHEMBL7211272	0.97	TK2 (0.34)	TK2RNASE1TK1TERT
SCHEMBL7206844	0.94	TK2 (0.35)	TK2RNASE1TK1TERT
SCHEMBL6831414	0.85	TK1 (0.38)	TK2TK1
SCHEMBL6831419	0.85	TK1 (0.38)	TK2TK1
SCHEMBL7208304	0.83	TK2 (0.32)	TK2TK1
SCHEMBL6830095	0.80	TK2 (0.35)	TK2RNASE1TK1
SCHEMBL7211250	0.80	TK2 (0.35)	TK2TK1
SCHEMBL6831427	0.80	RNASE1 (0.34)	TK2RNASE1TK1
SCHEMBL6829890	0.80	TK2 (0.34)	TK2TK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-6610837-B1	Preparation of an oligonucleotide compound of given formula by reacting with given compounds, followed by oxidation or sulfurization	ISIS PHARMACEUTICALS, INC.	2003-08-26	—	—	US	disclosed
US-6121437-A	SYNTHESIS OF OLIGONUCLEOTIDES USING OLIGONUCLEOTIDES OR NUCLEOTIDES WITH PROTECTED INTERNUCLEOSIDIC PHOSPHORUS FUNCTIONALITIES WHICH CAN BE REMOVED UNDER MILD CONDITIONS AND PRODUCE NONTOXIC BY-PRODUCTS	ISIS PHARMACEUTICALS, INC. (US)	2000-09-19	—	—	US	disclosed