Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LSS | P48449 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7211436 | 1.00 | LMNA (0.39) | LMNAMAPTLSSSMN1; SMN2ALDH1A1 | |
| SCHEMBL7209307 | 0.89 | SMN1; SMN2 (0.47) | LMNAMAPTSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL7208602 | 0.89 | LMNA (0.41) | LMNAMAPTLSSSMN1; SMN2KDM4E | |
| SCHEMBL7208600 | 0.89 | LMNA (0.41) | LMNAMAPTLSSSMN1; SMN2KDM4E | |
| SCHEMBL7205073 | 0.88 | ALDH1A1 (0.46) | LMNALSSALDH1A1PTBP1CCKBR | |
| SCHEMBL7205075 | 0.88 | ALDH1A1 (0.46) | LMNALSSALDH1A1PTBP1CCKBR | |
| SCHEMBL4803673 | 0.88 | LSS (0.46) | LMNAMAPTLSSSMN1; SMN2KDM4E | |
| SCHEMBL7211279 | 0.88 | LMNA (0.37) | LMNAMAPTLSSSMN1; SMN2KDM4E | |
| SCHEMBL4803666 | 0.88 | LSS (0.46) | LMNAMAPTLSSSMN1; SMN2KDM4E | |
| SCHEMBL7208794 | 0.85 | LMNA (0.42) | LMNAMAPTLSSSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1311475-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-05-21 | — | — | EP | disclosed |
| WO-2002014267-A1 | NOVEL AMINOCYCLOHEXANE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-21 | — | — | WO | disclosed |