Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | CXCR2 | P25025 | 7/20 | 0.44 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7211780 | 0.89 | CXCR2 (0.50) | NAMPTCXCR2MEN1KMT2ALMNA | |
| SCHEMBL7211897 | 0.85 | CXCR2 (0.50) | CXCR2CX3CR1MEN1KMT2AMAPT | |
| SCHEMBL7211784 | 0.81 | CXCR2 (0.51) | CXCR2CX3CR1MEN1KMT2ALMNA | |
| SCHEMBL7217938 | 0.81 | NAMPT (0.49) | NAMPTLMNAMAPTCNR1 | |
| SCHEMBL7212951 | 0.78 | NAMPT (0.46) | NAMPTMEN1KMT2ALMNAMAPT | |
| SCHEMBL6549708 | 0.77 | MEN1 (0.68) | CXCR2CX3CR1MEN1KMT2ALMNA | |
| SCHEMBL6564085 | 0.75 | CXCR2 (0.59) | CXCR2CX3CR1 | |
| SCHEMBL7211781 | 0.75 | NAMPT (0.47) | NAMPTMEN1KMT2ALMNAMAPT | |
| SCHEMBL4588723 | 0.74 | CXCR2 (0.60) | CXCR2CX3CR1DRD2 | |
| SCHEMBL7212993 | 0.73 | CXCR2 (0.54) | CXCR2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237548-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-07-23 | — | — | EP | claimed |
| EP-1237548-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-09-11 | — | — | EP | claimed |
| WO-2001034141-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-05-17 | — | — | WO | claimed |
| EP-1237548-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-07-23 | — | — | EP | disclosed |
| EP-1237548-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001034141-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-05-17 | — | — | WO | disclosed |