Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7211781 | 0.91 | NAMPT (0.47) | NAMPTCNR1SMN1; SMN2CA1CA2 | |
| SCHEMBL7217938 | 0.84 | NAMPT (0.49) | NAMPTCNR1CA1CA2MAPT | |
| SCHEMBL7216748 | 0.82 | ALDH1A1 (0.45) | CA1CA2ALDH1A1MAPTHSP90AA1 | |
| SCHEMBL7119944 | 0.80 | RORC (0.55) | NAMPTCNR1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7212958 | 0.78 | NAMPT (0.45) | NAMPTCNR1MEN1KMT2AALDH1A1 | |
| SCHEMBL7211780 | 0.77 | CXCR2 (0.50) | NAMPTCNR1CA1CA2MEN1 | |
| SCHEMBL29545958 | 0.76 | LMNA (0.58) | NAMPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL29546315 | 0.75 | ALDH1A1 (0.48) | NAMPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL6550860 | 0.73 | MEN1 (0.56) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL1717941 | 0.73 | MAPT (0.56) | NAMPTCNR1SMN1; SMN2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237548-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-07-23 | — | — | EP | disclosed |
| EP-1237548-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001034141-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-05-17 | — | — | WO | disclosed |