Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 5/20 | 0.45 |
| ▸ | CA1 | P00915 | 5/20 | 0.45 |
| ▸ | CA2 | P00918 | 5/20 | 0.45 |
| ▸ | CA9 | Q16790 | 5/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.44 |
| ▸ | STK17B | O94768 | 1/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7216748 | 0.82 | ALDH1A1 (0.45) | MAOAMAOBTDP1CA12CA1 | |
| SCHEMBL7217938 | 0.81 | NAMPT (0.49) | TDP1CA1CA2NPSR1 | |
| SCHEMBL7211897 | 0.78 | CXCR2 (0.50) | DRD2 | |
| SCHEMBL7212993 | 0.77 | CXCR2 (0.54) | TDP1CA12CA1CA2CA9 | |
| SCHEMBL7213015 | 0.76 | ALDH1A1 (0.46) | MAOAMAOBTDP1CA12CA1 | |
| SCHEMBL6563429 | 0.76 | CXCR1 (0.45) | MAOAMAOBTDP1CA12CA1 | |
| SCHEMBL22939550 | 0.74 | TDP1 (0.55) | MAOAMAOBTDP1CA12CA1 | |
| SCHEMBL3904926 | 0.74 | TDP1 (0.55) | MAOAMAOBTDP1CA12CA1 | |
| SCHEMBL6563501 | 0.74 | CXCR2 (0.42) | CA12CA1CA2CA9STK17B | |
| SCHEMBL30448505 | 0.73 | HDAC1 (0.48) | MAOAMAOBTDP1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237548-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2003-07-23 | — | — | EP | disclosed |
| EP-1237548-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001034141-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-05-17 | — | — | WO | disclosed |