Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.61 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7210344 | 0.85 | PTGS2 (1.00) | PTGS2PTGS1CHRNA7 | |
| SCHEMBL5311097 | 0.82 | PTGS2 (0.77) | PTGS2PTGS1CHRNA7 | |
| SCHEMBL7215274 | 0.82 | PTGS2 (1.00) | PTGS2PTGS1CHRNA7 | |
| SCHEMBL1382367 | 0.80 | PTGS2 (0.78) | PTGS2PTGS1CHRNA7 | |
| SCHEMBL5965074 | 0.79 | PTGS2 (0.76) | PTGS2PTGS1 | |
| SCHEMBL7212067 | 0.79 | PTGS2 (0.76) | PTGS2PTGS1 | |
| SCHEMBL3823939 | 0.78 | PTGS2 (0.69) | PTGS2PTGS1 | |
| SCHEMBL3823932 | 0.78 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL470376 | 0.78 | PTGS2 (0.81) | PTGS2PTGS1 | |
| SCHEMBL2211020 | 0.77 | NOTUM (0.67) | PTGS2CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935990-A | PYRROLYL DERIVATIVES HAVING AT POSITION 1 OR 5 A PHENYL SUBSTITUTED WITH METHYLSULFONYL OR AMINOSULFONYL; INHIBIT CYCLOOXYGENASE-2 FOR USE TREATMENT OF INFLAMMATION, AS AN ANALGESIC, OR AS AN ANTIPYRETIC | G.D. SEARLE & CO. (US) | 1999-08-10 | — | — | US | claimed |
| EP-1369415-A1 | Substituted pyrrolyl compounds for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2003-12-10 | — | — | EP | disclosed |
| EP-0946507-A1 | SUBSTITUTED PYRROLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1999-10-06 | — | — | EP | disclosed |
| US-5935990-A | PYRROLYL DERIVATIVES HAVING AT POSITION 1 OR 5 A PHENYL SUBSTITUTED WITH METHYLSULFONYL OR AMINOSULFONYL; INHIBIT CYCLOOXYGENASE-2 FOR USE TREATMENT OF INFLAMMATION, AS AN ANALGESIC, OR AS AN ANTIPYRETIC | G.D. SEARLE & CO. (US) | 1999-08-10 | — | — | US | disclosed |
| WO-1998025896-A1 | SUBSTITUTED PYRROLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-06-18 | — | — | WO | disclosed |