Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 7/20 | 0.68 |
| ▸ | MAOB | P27338 | 2/20 | 0.65 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.62 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.53 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20830738 | 0.90 | NR4A2 (0.74) | NR4A2MAOBSMPD1SRD5A2PTPN1 | |
| SCHEMBL9574667 | 0.88 | NR4A2 (0.72) | NR4A2MAOBSMPD1SRD5A2PTPN1 | |
| SCHEMBL340106 | 0.86 | MAOB (0.69) | NR4A2MAOBSMPD1SRD5A2PTPN1 | |
| SCHEMBL10917971 | 0.85 | TDP1 (0.69) | KMT2AALDH1A1 | |
| SCHEMBL27973888 | 0.84 | NR4A2 (0.74) | NR4A2MAOBSMPD1SRD5A2PTPN1 | |
| SCHEMBL7337987 | 0.82 | NR4A2 (0.72) | NR4A2MAOBSMPD1SRD5A2PTPN1 | |
| SCHEMBL976424 | 0.82 | MAOB (0.73) | NR4A2MAOBSMPD1SRD5A2PTPN1 | |
| SCHEMBL30412034 | 0.82 | MAOB (0.73) | NR4A2MAOBSMPD1SRD5A2PTPN1 | |
| SCHEMBL30412560 | 0.82 | NR4A2 (0.77) | NR4A2MAOBSMPD1SRD5A2PTPN1 | |
| SCHEMBL340107 | 0.82 | NR4A2 (0.77) | NR4A2MAOBSMPD1SRD5A2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620799-B2 | Water soluble prodrugs of azole compounds | BRISTOL-MYERS SQUIBB COMPANY | 2003-09-16 | — | — | US | disclosed |
| US-6620934-B2 | A triazole antifungal compounds having a phosphate group | BRISTOL-MYERS SQUIBB COMPANY | 2003-09-16 | — | — | US | disclosed |
| US-6458961-B1 | TRIAZOLE CONTAINING FUNGICIDES; PHOSPHATE IS LINKED TO (2R,3R)-3-(4-(4-CYANOPHENYL)THIAZOL-2-YL)-2-(2,4-DIFLUOROPHENY L) -1-(1H-1,2,4-TRIAZOL-1-YL)-BUTAN-2-OL | BRISTOL-MYERS SQUIBB COMPANY | 2002-10-01 | — | — | US | disclosed |
| US-20020049216-A1 | Water soluble prodrugs of azole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2002-04-25 | — | — | US | disclosed |
| US-20020049334-A1 | Triazole containing fungicides such as (2R,3R)-3-(4-(4-cyano phenyl)thiazol-2-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazo l-1-yl)-2-(((o-phosphonooxy)benzoyloxy)methoxy)butane | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2002-04-25 | — | — | US | disclosed |
| US-20020049336-A1 | Water soluble prodrugs of azole compounds | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2002-04-25 | — | — | US | disclosed |
| WO-2000030655-A1 | WATER SOLUBLE PRODRUGS OF AZOLE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-06-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020049336-A1 | Water soluble prodrugs of azole compounds | CYP51A1, ERG28, CYP3A7 | NR4A2 582/4885MAOB 2752/4885SMPD1 1911/4885 |
| US-20020049216-A1 | Water soluble prodrugs of azole compounds | CYP51A1, ERG28, CYP3A7 | NR4A2 582/4885MAOB 2752/4885SMPD1 1911/4885 |
| US-20020049334-A1 | Triazole containing fungicides such as (2R,3R)-3-(4-(4-cyano phenyl)thiazol-2-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazo l-1-yl)-2-(((o-phosphonooxy)benzoyloxy)methoxy)butane | CYP51A1, CYP4B1, TH | NR4A2 191/4885MAOB 3225/4885SMPD1 2862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.