Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | PDE2A | O00408 | 1/20 | 0.55 |
| ▸ | PDE5A | O76074 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.55 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7212793 | 0.85 | ALDH1A1 (0.59) | ALDH1A1CYP3A4PDE2APDE5AALOX15 | |
| SCHEMBL3016852 | 0.82 | CA12 (0.45) | ALDH1A1ALOX15MEN1KMT2ANPC1 | |
| SCHEMBL29451866 | 0.81 | VCAM1 (0.59) | ALDH1A1CYP3A4PDE2APDE5AALOX15 | |
| SCHEMBL7212546 | 0.81 | ALDH1A1 (0.55) | ALDH1A1CYP3A4PDE2APDE5AALOX15 | |
| SCHEMBL7212568 | 0.81 | ALDH1A1 (0.59) | ALDH1A1CYP3A4PDE2APDE5AALOX15 | |
| SCHEMBL29451638 | 0.81 | ALDH1A1 (0.59) | ALDH1A1CYP3A4PDE2APDE5AALOX15 | |
| SCHEMBL29451520 | 0.81 | ALDH1A1 (0.51) | ALDH1A1CYP3A4PDE2APDE5AALOX15 | |
| SCHEMBL7212557 | 0.81 | ALDH1A1 (0.51) | ALDH1A1CYP3A4PDE2APDE5AALOX15 | |
| SCHEMBL7212524 | 0.79 | ALDH1A1 (0.52) | ALDH1A1CYP3A4PDE2APDE5AALOX15 | |
| SCHEMBL29451504 | 0.79 | ALDH1A1 (0.52) | ALDH1A1CYP3A4PDE2APDE5AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6617357-B2 | Administering to a patient for inhibiting cyclic nucleotide phosphodiesterases (PDEs) activity, a benzenesulfonamide compound | SMITHKLINE BEECHAM CORPORATION | 2003-09-09 | — | — | US | disclosed |
| US-20020156064-A1 | Compounds and their use as PDE inhibitors | SMITHKLINE BEECHAM CORP | 2002-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156064-A1 | Compounds and their use as PDE inhibitors | PDE3A, PDE2A, PDE5A | ALDH1A1 632/4885CYP3A4 1168/4885PDE2A 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.