Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | PDE2A | O00408 | 1/20 | 0.55 |
| ▸ | PDE5A | O76074 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.55 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7212568 | 1.00 | ALDH1A1 (0.59) | ALDH1A1MEN1KMT2APOLBPKM | |
| SCHEMBL7212793 | 0.85 | ALDH1A1 (0.59) | ALDH1A1MEN1KMT2APOLBPKM | |
| SCHEMBL8298291 | 0.83 | ALDH1A1 (0.64) | ALDH1A1MEN1KMT2APOLBPKM | |
| SCHEMBL29451866 | 0.81 | VCAM1 (0.59) | ALDH1A1MEN1KMT2APOLBPKM | |
| SCHEMBL7212867 | 0.81 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2APOLBPKM | |
| SCHEMBL7212546 | 0.81 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2APOLBPKM | |
| SCHEMBL29451695 | 0.79 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2APOLBPKM | |
| SCHEMBL29451612 | 0.79 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2APOLBPKM | |
| SCHEMBL29451504 | 0.79 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2APOLBPKM | |
| SCHEMBL29452058 | 0.79 | ALDH1A1 (0.52) | ALDH1A1MEN1KMT2APOLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022032144-A1 | SUBSTRATE ADAPTOR INHIBITORS OF PRMT5 AND USES THEREOF | THE BROAD INSTITUTE, INC. (US) | 2022-02-10 | — | — | WO | disclosed |