Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.47 |
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CETP | P11597 | 3/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7212927 | 0.87 | S1PR4 (0.38) | NPC1RAB9ATSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL4268814 | 0.80 | ELANE (0.40) | NPC1RAB9AALDH1A1KDM4EMEN1 | |
| SCHEMBL12496567 | 0.78 | NPC1 (0.50) | NPC1RAB9AALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL7207839 | 0.77 | KCNN4 (0.38) | PTPN1ALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL1811808 | 0.76 | RAB9A (0.46) | NPC1RAB9AALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7214230 | 0.73 | NPC1 (0.50) | NPC1RAB9ATSHRCETPALDH1A1 | |
| SCHEMBL7214212 | 0.73 | NPC1 (0.47) | NPC1RAB9ATSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL4265208 | 0.73 | NPC1 (0.47) | NPC1RAB9ATSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL7212923 | 0.71 | NPC1 (0.44) | NPC1RAB9A | |
| SCHEMBL7208522 | 0.71 | NPC1 (0.44) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150988-B1 | PHOSPHORAMIDATE, AND MONO-, DI-, AND TRI-PHOSPHATE ESTERS OF (1R, CIS)-4-(6-AMINO-9H-PURIN-9-YL)-2-CYCLOPENTENE-1-METHANOL AS ANTIVIRAL AGENTS | GLAXO GROUP LTD (GB) | 2003-05-28 | — | — | EP | claimed |