Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL946382 | 1.00 | TDP1 (0.56) | TDP1ALDH1A1HSD17B10TSHRCYP3A4 | |
| SCHEMBL9843461 | 0.80 | CA1 (0.47) | TDP1ALDH1A1HSD17B10TSHRCYP3A4 | |
| SCHEMBL10696690 | 0.80 | GAA (0.47) | TDP1ALDH1A1HSD17B10TSHRCYP3A4 | |
| SCHEMBL10521871 | 0.78 | GAA (0.44) | CYP3A4L3MBTL1GAAMAPK1KDM4E | |
| SCHEMBL674003 | 0.78 | MEN1 (0.43) | TDP1ALDH1A1HSD17B10TSHRCYP3A4 | |
| SCHEMBL10521875 | 0.78 | GAA (0.44) | CYP3A4L3MBTL1GAAMAPK1KDM4E | |
| SCHEMBL141473 | 0.77 | TDP1 (0.56) | TDP1ALDH1A1HSD17B10TSHRCYP3A4 | |
| SCHEMBL965457 | 0.77 | TDP1 (0.56) | TDP1ALDH1A1HSD17B10TSHRCYP3A4 | |
| SCHEMBL4624736 | 0.77 | FDPS (0.51) | ALDH1A1CYP3A4LMNAHIF1AKDM4E | |
| SCHEMBL1713201 | 0.77 | RAB9A (0.47) | ALDH1A1HSD17B10CYP3A4LMNAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5122511-A | IMMUNOSUPPRESSIVE CYCLOSPORIN ANALOGS WITH MODIFIED AMINO ACIDS AT POSITION-8 | MERCK & CO., INC. (US) | 1992-06-16 | — | — | US | claimed |
| EP-0444897-A1 | Novel immunosuppressive cyclosporin analogs with modified amino acids at position-8 | MERCK & CO. INC. (US) | 1991-09-04 | — | — | EP | claimed |
| EP-0149581-B1 | COMPOSITIONS CONTAINING OLIGO-MURAMYLPEPTIDES AND THEIR APPLICATION, IN PARTICULAR FOR THE ACTIVATION OF MACROPHAGES | ANVAR Agence Nationale de Valorisation de la Recherche (FR) | 1987-07-22 | — | — | EP | claimed |
| US-4663311-A | Derivatives of muramyl-peptides and of steroids having macrophage-activating properties | TENU JEAN P (FR) | 1987-05-05 | — | — | US | claimed |
| US-6617127-B2 | Using N-formylaspartylphenylalanine compound | HOLLAND SWEETENER COMPANY, V.O.F. (NL) | 2003-09-09 | — | — | US | disclosed |
| US-6579696-B1 | Comprising diaminobutyric acid having a gamma amino group and amino acid selected from cysteine, alanine and lysine; use in prevention and treatment of sepsis | PROMEGA CORPORATION | 2003-06-17 | — | — | US | disclosed |
| EP-0698600-B1 | Composition, method and test device for determining the presence of leukocyte cells, esterase or protease in a test sample | BAYER AG (US) | 1999-11-10 | — | — | EP | disclosed |
| EP-0840619-A1 | PREVENTION AND TREATMENT OF SEPSIS | OPHIDIAN PHARMACEUTICALS, INC. (US) | 1998-05-13 | — | — | EP | disclosed |
| US-5663297-A | OLIGOPEPTIDES | HOFFMANN-LA ROCHE INC. (US) | 1997-09-02 | — | — | US | disclosed |
| WO-1996040251-A1 | PREVENTION AND TREATMENT OF SEPSIS | OPHIDIAN PHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |
| EP-0698600-A1 | Composition, method and test device for determining the presence of leukocyte cells, esterase or protease in a test sample | Bayer Corporation (US) | 1996-02-28 | — | — | EP | disclosed |
| US-5464739-A | Urinalysis, hydrolysis of lactate ester | BAYER CORPORATION (US) | 1995-11-07 | — | — | US | disclosed |
| US-5214130-A | Synthesis of novel immunosuppressive cyclosporin analogs with modified amino acids at position-8 | MERCK & CO., INC. (US) | 1993-05-25 | — | — | US | disclosed |
| US-5122511-A | IMMUNOSUPPRESSIVE CYCLOSPORIN ANALOGS WITH MODIFIED AMINO ACIDS AT POSITION-8 | MERCK & CO., INC. (US) | 1992-06-16 | — | — | US | disclosed |
| EP-0444897-A1 | Novel immunosuppressive cyclosporin analogs with modified amino acids at position-8 | MERCK & CO. INC. (US) | 1991-09-04 | — | — | EP | disclosed |
| US-4647553-A | Gonadoliberin derivatives and process for the preparation thereof | INNOVACIOS ALAP KOZPONTI VALTO ES HITELBANK RT. (HU) | 1987-03-03 | — | — | US | disclosed |
| US-4647553-A | Gonadoliberin derivatives and process for the preparation thereof | INNOVACIOS ALAP KOZPONTI VALTO ES HITELBANK RT. (HU) | 1987-03-03 | — | — | US | disclosed |
| US-4647552-A | Process for obtaining ready for fertilization sexual products from sexually mature fish | KOZPONTI VALTO-ES HITELBANK RT. INNOVACIOS ALAP (HU) | 1987-03-03 | — | — | US | disclosed |
| US-4647552-A | Process for obtaining ready for fertilization sexual products from sexually mature fish | KOZPONTI VALTO-ES HITELBANK RT. INNOVACIOS ALAP (HU) | 1987-03-03 | — | — | US | disclosed |