Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 11/20 | 0.52 |
| ▸ | SHBG | P04278 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7242829 | 0.80 | LMNA (0.58) | CYP19A1SHBGCYP3A4LMNAHIF1A | |
| SCHEMBL18157022 | 0.71 | LMNA (0.79) | CYP19A1SHBGCYP3A4LMNANFKB1 | |
| SCHEMBL8013917 | 0.71 | LMNA (0.79) | CYP19A1SHBGCYP3A4LMNANFKB1 | |
| SCHEMBL18220875 | 0.71 | LMNA (0.79) | CYP19A1SHBGCYP3A4LMNANFKB1 | |
| SCHEMBL18218174 | 0.71 | LMNA (0.79) | CYP19A1SHBGCYP3A4LMNANFKB1 | |
| SCHEMBL7176569 | 0.71 | AR (0.44) | CYP19A1SHBGCYP3A4LMNANR3C1 | |
| SCHEMBL7176565 | 0.71 | AR (0.44) | CYP19A1SHBGCYP3A4LMNANR3C1 | |
| SCHEMBL20991078 | 0.71 | LMNA (0.60) | CYP19A1SHBGCYP3A4LMNANFKB1 | |
| SCHEMBL10887748 | 0.69 | CYP3A4 (0.59) | CYP19A1SHBGCYP3A4LMNANFKB1 | |
| SCHEMBL10887764 | 0.69 | CYP3A4 (0.59) | CYP19A1SHBGCYP3A4LMNANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289507-A1 | USE OF AN ALDOSTERONE ANTAGONIST FOR THE TREATMENT OR PROHPYLAXIS OF ALDOSTERONE-MEDIATED PATHOGENIC EFFECTS | Pharmacia Corporation (US) | 2003-03-12 | — | — | EP | disclosed |
| EP-1227804-A2 | USE OF AN ALDOSTERONE ANTAGONIST FOR TREATING RESTENOSIS | Pharmacia Corporation (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001095892-A1 | USE OF AN ALDOSTERONE ANTAGONIST FOR THE TREATMENT OR PROHPYLAXIS OF ALDOSTERONE-MEDIATED PATHOGENIC EFFECTS | PHARMACIA CORPORATION (US) | 2001-12-20 | — | — | WO | disclosed |
| WO-2001034132-A2 | USE OF AN ALDOSTERONE ANTAGONIST FOR TREATING RESTENOSIS | PHARMACIA CORPORATION (US) | 2001-05-17 | — | — | WO | disclosed |