Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.69 |
| ▸ | PGR | P06401 | 8/20 | 0.57 |
| ▸ | GHSR | Q92847 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propane SCHEMBL7213474 | 0.86 | HTR6 (0.70) | HTR6PGRGHSRPKMMAPT | |
| SCHEMBL3125892 | 0.82 | HTR6 (1.00) | HTR6GHSRPKMMAPT | |
| SCHEMBL7211617 | 0.77 | HTR6 (0.57) | HTR6PGRPKMMAPTLMNA | |
| SCHEMBL8442223 | 0.77 | TAAR1 (0.71) | — | |
| SCHEMBL7206689 | 0.77 | HTR6 (0.63) | HTR6GHSRPKM | |
| SCHEMBL1800551 | 0.75 | TAAR1 (0.74) | — | |
| SCHEMBL17894501 | 0.75 | PGR (0.56) | HTR6PGRPKMMAPTLMNA | |
| SCHEMBL30737484 | 0.74 | PGR (0.71) | HTR6PGRPKMMAPTLMNA | |
| SCHEMBL16431575 | 0.74 | PGR (0.71) | HTR6PGRPKMMAPTLMNA | |
| SCHEMBL3756876 | 0.74 | PGR (1.00) | PGRPKMMAPTLMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077935-B1 | PHENYLSULFONAMIDE-PHENYLETHYLAMINES USEFUL AS DOPAMINE RECEPTORS | UPJOHN CO (US) | 2003-10-29 | — | — | EP | claimed |
| EP-1077935-A1 | PHENYLSULFONAMIDE-PHENYLETHYLAMINES USEFUL AS DOPAMINE RECEPTORS | PHARMACIA & UPJOHN COMPANY (US) | 2001-02-28 | — | — | EP | claimed |
| US-6103766-A | SUBSTITUTED OR UNSUBSTITUTED PHENYLSULFONAMIDE-PHENYLAMINE DERIVATIVES USEFUL FOR TREATING THE DISORDERS RELATED TO CENTRAL NERVOUS SYSTEM | PHARMACIA & UPJOHN COMPANY (US) | 2000-08-15 | — | — | US | claimed |
| WO-1999058499-A1 | PHENYLSULFONAMIDE-PHENYLETHYLAMINES USEFUL AS DOPAMINE RECEPTORS | PHARMACIA & UPJOHN COMPANY (US) | 1999-11-18 | — | — | WO | claimed |
| EP-1077935-B1 | PHENYLSULFONAMIDE-PHENYLETHYLAMINES USEFUL AS DOPAMINE RECEPTORS | UPJOHN CO (US) | 2003-10-29 | — | — | EP | disclosed |
| US-6103766-A | SUBSTITUTED OR UNSUBSTITUTED PHENYLSULFONAMIDE-PHENYLAMINE DERIVATIVES USEFUL FOR TREATING THE DISORDERS RELATED TO CENTRAL NERVOUS SYSTEM | PHARMACIA & UPJOHN COMPANY (US) | 2000-08-15 | — | — | US | disclosed |