Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 15/20 | 0.48 |
| ▸ | RXRB | P28702 | 3/20 | 0.48 |
| ▸ | RXRG | P48443 | 3/20 | 0.48 |
| ▸ | RARA | P10276 | 2/20 | 0.48 |
| ▸ | RARB | P10826 | 2/20 | 0.48 |
| ▸ | RARG | P13631 | 2/20 | 0.48 |
| ▸ | HNF4A | P41235 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7207907 | 0.91 | RXRA (0.47) | RXRARXRBRXRGRARARARB | |
| SCHEMBL8810710 | 0.82 | RXRA (0.36) | RXRARXRBRXRGRARARARB | |
| SCHEMBL7212264 | 0.80 | RXRA (0.36) | RXRARXRBRXRGRARARARB | |
| SCHEMBL28648665 | 0.80 | LMNA (0.48) | ERN1KDM4EALDH1A1MDM2 | |
| SCHEMBL6878500 | 0.80 | RXRA (0.46) | RXRARXRBRXRGRARARARB | |
| SCHEMBL6917408 | 0.79 | RXRA (0.49) | RXRARXRBRXRGRARARARB | |
| SCHEMBL727912 | 0.79 | RXRA (0.46) | RXRARXRBRXRGRARARARB | |
| SCHEMBL7713216 | 0.79 | ALDH1A1 (0.55) | RXRARXRBRXRGRARARARB | |
| SCHEMBL6917452 | 0.77 | RXRA (0.47) | RXRARXRBRXRGRARARARB | |
| SCHEMBL6477145 | 0.77 | RXRA (0.49) | RXRARXRBRXRGRARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6610877-B1 | Treating photo and/or age damaged skin | HOFFMAN-LA ROCHE INC. | 2003-08-26 | — | — | US | disclosed |
| EP-0641759-B1 | Use of aromatic carboxylic derivatives for the preparation of drugs | HOFFMANN LA ROCHE (CH) | 1998-12-09 | — | — | EP | disclosed |
| US-5700836-A | TOPICALLY ADMINISTERING TO TREAT PHOTODAMAGED SKIN | HOFFMANN-LA ROCHE INC. (US) | 1997-12-23 | — | — | US | disclosed |
| EP-0641759-A1 | Aromatic carboxylic acid derivatives, their preparation and drugs containing these derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-03-08 | — | — | EP | disclosed |