Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Taurine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.82 |
| ▸ | BLM | P54132 | 3/20 | 0.82 |
| ▸ | SLC6A6 | P31641 | 1/20 | 0.82 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.82 |
| ▸ | APP | P05067 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | NT5E | P21589 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA6 | P23280 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Taurine SCHEMBL1826395 | 1.00 | LMNA (0.82) | LMNABLMSLC6A6CYP2C19APP | |
| Taurine SCHEMBL27709203 | 0.97 | LMNA (0.78) | LMNABLMSLC6A6CYP2C19APP | |
| Taurine SCHEMBL8698527 | 0.94 | LMNA (0.82) | LMNABLMSLC6A6CYP2C19APP | |
| Taurine SCHEMBL9902206 | 0.92 | LMNA (0.70) | LMNABLMSLC6A6CYP2C19APP | |
| Taurine SCHEMBL42632 | 0.91 | BLM (1.00) | LMNABLMSLC6A6CYP2C19APP | |
| Taurine SCHEMBL30191395 | 0.91 | — | — | |
| Taurine SCHEMBL23068 | 0.91 | — | — | |
| Taurine SCHEMBL30179154 | 0.91 | — | — | |
| Monoethanolamine SCHEMBL9784964 | 0.88 | LMNA (0.63) | LMNABLMSLC6A6CYP2C19APP | |
| Taurine SCHEMBL3667691 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101678152-B | Methods for pre-stressing and capping bioprosthetic tissue | EDWARDS LIFESCIENCES CORP | 2013-06-26 | — | — | CN | disclosed |
| CN-101678152-A | methods for pre-stressing and capping bioprosthetic tissue | EDWARDS LIFESCIENCES CORP | 2010-03-24 | — | — | CN | disclosed |
| US-6617390-B2 | Catalytic polymerization of acrylic acid-acrylonitrile block copolymer; improved hydrophobic/hydrophilic distribution; thermal stability | REPLICATION MEDICAL, INC. | 2003-09-09 | — | — | US | disclosed |
| US-20020193531-A1 | Method of making synthetic hydrophilic polymers and products resulting therefrom | REPLICATION MEDICAL, INC. | 2002-12-19 | — | — | US | disclosed |
| US-6451922-B2 | TWO STAGE CATALYTIC REACTION OF POLYACRYLONITRILE IN PRESENCE AND ABSENCE OF SOLVENT TO FORM MULTIBLOCK POLYMER OF ACRYLIC ACID SALT, ACRYLAMIDE AND ACRYLIC ACID DERIVATIVE; MECHANICAL AND THERMAL STABILITY; COSMETICS; THICKENER; EMULSIFIER | REPLICATION MEDICAL, INC. | 2002-09-17 | — | — | US | disclosed |
| US-20010044502-A1 | Method of making synthetic hydrophilic polymers and products resulting therefrom | REPLICATION MEDICAL, INC. | 2001-11-22 | — | — | US | disclosed |