Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12556748 | 0.83 | KMT2A (0.56) | ALDH1A1L3MBTL1KMT2AMAPTHPGD | |
| SCHEMBL16480969 | 0.82 | CA1 (0.54) | ALDH1A1L3MBTL1KMT2AMAPTHPGD | |
| SCHEMBL5091783 | 0.82 | ALDH1A1 (0.51) | GSRALDH1A1KMT2AHPGDGAA | |
| SCHEMBL1832815 | 0.81 | KMT2A (0.50) | ALDH1A1L3MBTL1KMT2AMAPTHPGD | |
| SCHEMBL12556797 | 0.81 | KMT2A (0.50) | ALDH1A1L3MBTL1KMT2AMAPTHPGD | |
| SCHEMBL1832685 | 0.81 | LMNA (0.57) | ALDH1A1L3MBTL1KMT2AMAPTHPGD | |
| SCHEMBL1818434 | 0.81 | KMT2A (0.63) | ALDH1A1L3MBTL1KMT2AMAPTHPGD | |
| SCHEMBL1821483 | 0.79 | MMP1 (0.55) | ALDH1A1L3MBTL1KMT2AMAPT | |
| SCHEMBL10749473 | 0.78 | KMT2A (0.61) | ALDH1A1L3MBTL1KMT2AMAPTHPGD | |
| SCHEMBL1374042 | 0.77 | HSD17B3 (0.61) | ALDH1A1L3MBTL1KMT2AMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1369415-A1 | Substituted pyrrolyl compounds for the treatment of inflammation | G.D. SEARLE & CO. (US) | 2003-12-10 | — | — | EP | disclosed |
| EP-0946507-A1 | SUBSTITUTED PYRROLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1999-10-06 | — | — | EP | disclosed |
| US-5935990-A | PYRROLYL DERIVATIVES HAVING AT POSITION 1 OR 5 A PHENYL SUBSTITUTED WITH METHYLSULFONYL OR AMINOSULFONYL; INHIBIT CYCLOOXYGENASE-2 FOR USE TREATMENT OF INFLAMMATION, AS AN ANALGESIC, OR AS AN ANTIPYRETIC | G.D. SEARLE & CO. (US) | 1999-08-10 | — | — | US | disclosed |
| WO-1998025896-A1 | SUBSTITUTED PYRROLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-06-18 | — | — | WO | disclosed |