SCHEMBL7214441

SCHEMBL7214441

O=C(Nc1ccccc1)c1cc(Br)ccc1NS(=O)(=O)c1ccccc1F

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR27 Q9NS67 8/20 0.57
SLC10A2 Q12908 1/20 0.57
SLC10A1 Q14973 1/20 0.57
SLC10A6 Q3KNW5 1/20 0.57
CYP3A4 P08684 1/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
LMNA P02545 4/20 0.52
MEN1 O00255 3/20 0.52
KMT2A Q03164 3/20 0.52
MAPT P10636 2/20 0.52
HTT P42858 1/20 0.52
AVPR2 P30518 2/20 0.51
ALDH1A1 P00352 3/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
NPC1 O15118 1/20 0.50
RAB9A P51151 1/20 0.50
KAT6A Q92794 1/20 0.47
METAP2 P50579 1/20 0.47
TP53 P04637 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7117455 0.95 SLC10A2 (0.60) GPR27SLC10A2SLC10A1SLC10A6CYP3A4
SCHEMBL7208733 0.91 SLC10A6 (0.71) GPR27SLC10A2SLC10A1SLC10A6CYP3A4
SCHEMBL7208746 0.85 TSHR (0.58) SLC10A2SLC10A1SLC10A6CYP3A4CYP2C9
SCHEMBL7213183 0.84 SLC10A6 (0.73) GPR27SLC10A2SLC10A1SLC10A6CYP3A4
SCHEMBL7128469 0.81 SLC10A2 (0.60) GPR27SLC10A2SLC10A1SLC10A6LMNA
SCHEMBL7120319 0.81 SLC10A6 (0.76) GPR27SLC10A2SLC10A1SLC10A6CYP3A4
SCHEMBL7128140 0.80 SLC10A6 (0.61) GPR27SLC10A2SLC10A1SLC10A6LMNA
SCHEMBL14113178 0.80 SLC10A6 (0.67) GPR27SLC10A2SLC10A1SLC10A6CYP3A4
SCHEMBL14113153 0.79 SLC10A6 (0.63) GPR27SLC10A2SLC10A1SLC10A6CYP3A4
SCHEMBL27575113 0.79 SLC10A6 (0.56) GPR27SLC10A2SLC10A1SLC10A6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1187531-A4 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2003-05-28 EP claimed
US-6458845-B1 METHOD OF ANTAGONIZING A MACROPHAGE SCAVENGER RECEPTOR COMPRISING ADMINISTERING TO A SUBJECT IN NEED OF TREATMENT AN EFFECTIVE AMOUNT OF AN N-PHENYL-2-(3-TRIFLUOROMETHYLPHENYLSULFONAMIDO)BENZAMIDE, A SMITHKLINE BEECHAM CORPORATION 2002-10-01 US claimed
CN-1358062-A Macrophage scavenger receptor antagonists SMITHKLINE BEECHAM CORP (US) 2002-07-10 CN claimed
EP-1187531-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SmithKline Beecham Corporation (US) 2002-03-20 EP claimed
WO-2001098264-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2001-12-27 WO claimed
WO-2000078145-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2000-12-28 WO claimed
EP-1187531-A4 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORP (US) 2003-05-28 EP disclosed
US-6458845-B1 METHOD OF ANTAGONIZING A MACROPHAGE SCAVENGER RECEPTOR COMPRISING ADMINISTERING TO A SUBJECT IN NEED OF TREATMENT AN EFFECTIVE AMOUNT OF AN N-PHENYL-2-(3-TRIFLUOROMETHYLPHENYLSULFONAMIDO)BENZAMIDE, A SMITHKLINE BEECHAM CORPORATION 2002-10-01 US disclosed
CN-1358062-A Macrophage scavenger receptor antagonists SMITHKLINE BEECHAM CORP (US) 2002-07-10 CN disclosed
EP-1187531-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SmithKline Beecham Corporation (US) 2002-03-20 EP disclosed
WO-2001098264-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2001-12-27 WO disclosed
WO-2000078145-A1 MACROPHAGE SCAVENGER RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 2000-12-28 WO disclosed